57659-03-7

Basic information

• Product Name: 6-Hydroxy Nicotinoyl Chloirde
• Synonyms: 6-Hydroxy Nicotinoyl Chloirde;3-PYRIDINECARBONYL CGLORIDE,1,6-DIHYDRO-6-OXO-
• CAS NO: 57659-03-7
• Molecular Formula: C₆H₄ClNO₂
• Molecular Weight: 157.55446
• Mol File: 57659-03-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Hydroxy Nicotinoyl Chloirde(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxy Nicotinoyl Chloirde(57659-03-7)
• EPA Substance Registry System: 6-Hydroxy Nicotinoyl Chloirde(57659-03-7)

Safety Data

• Hazardous Substances Data: 57659-03-7(Hazardous Substances Data)

Upstream product

• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 609-70-1 4-hydroxynicotinic acid 
• 5006-66-6 6-hydroxynicotinic acid 

Downstream Products

• 850664-28-7 N-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-6-{[2-(4-morpholinyl)ethyl]oxy}-3-pyridinecarboxamide 
• 923243-45-2 N-(4-fluorophenyl)-6-hydroxynicotinamide 
• 1571034-03-1 N-(2-hydroxy-1-(4-(trifluoromethoxy)phenyl)ethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide 
• 914386-62-2 N-[3-(4-fluorophenyl)-3-(4-methanesulfonylphenyl)propyl]-6-hydroxy-nicotinamide 
• 23312-67-6 1,6-Dihydro-6-oxo-1-(β-D-ribofuranosyl)-3-pyridincarbonsaeureamid 

Relevant articles and documents

Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability

Abstract The chemokine receptors CXCR1 and CXCR2 are important pharmaceutical targets due to their key roles in inflammatory diseases and cancer progression. We have previously identified 2-[5-(4-fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanylmethyl]-phenylboronic acid (SX-517) and 6-(2-boronic acid-5-trifluoromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide (SX-576) as potent non-competitive boronic acid-containing CXCR1/2 antagonists. Herein we report the synthesis and evaluation of aminopyridine and aminopyrimidine analogs of SX-517 and SX-576, identifying (2-{(benzyl)[(5-boronic acid-2-pyridyl)methyl]amino}-5-pyrimidinyl)(4-fluorophenylamino)formaldehyde as a potent chemokine antagonist with improved aqueous solubility and oral bioavailability.

6-SUBSTITUTED- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS

The present invention provides 6-substituted 2,3,4,5-tetrahydro-lH- benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: R6 D R? N-R" R* where R6 is -(CrC3)alkyl-S-(C0-C3)alkyl-R10, -(C1-C3)alkyl-NR11R12, -(CrC3)alkyl-O- R 13. and other substituents are as defined in the specification.

NOVEL CYANOGUANIDINE COMPOUNDS

Novel pyridyl cyanoguanidien compounds of general formula I (I) wherein R1, X, R2 and R3 are as defined herein, exhibit a high antiproliferative activity and may be used in the treatment of hyperproliferative and neoplastic diseases.