57723-01-0 Usage
Structure
Thiourea derivative
It contains a thiourea group (-NH-C(=S)-NH-) in its molecular structure.
Functional groups
Phenyl group, pyrrolidine ring, and ethyl group
The compound has a phenyl group (a ring of six carbon atoms with a hydrogen atom attached to each carbon), a pyrrolidine ring (a five-membered nitrogen-containing ring), and an ethyl group (a two-carbon chain with a hydrogen atom and a methyl group attached to one of the carbons) attached to the nitrogen atom.
Usage in pharmaceutical research
Potential drug candidate
Due to its unique structure and potential biological activities, 1-phenyl-3-[2-(pyrrolidin-1-yl)ethyl]thiourea is commonly used in pharmaceutical research as a potential drug candidate.
Biological activities
Antitumor, antiviral, and anti-inflammatory properties
The compound has been studied for its potential to exhibit antitumor, antiviral, and anti-inflammatory properties, which could make it useful in the development of new drugs for various diseases.
Acetylcholinesterase inhibition potential
1-phenyl-3-[2-(pyrrolidin-1-yl)ethyl]thiourea has also been investigated for its potential to inhibit the enzyme acetylcholinesterase, which is involved in the breakdown of the neurotransmitter acetylcholine in the brain.
Possible treatment for neurodegenerative diseases
Due to its acetylcholinesterase inhibition potential, the compound could be a candidate for the treatment of neurodegenerative diseases such as Alzheimer's, which is characterized by the progressive loss of memory and cognitive functions.
Need for further research
Despite its potential, more research is needed to fully understand the biological activities and therapeutic potential of 1-phenyl-3-[2-(pyrrolidin-1-yl)ethyl]thiourea.
Check Digit Verification of cas no
The CAS Registry Mumber 57723-01-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,7,2 and 3 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 57723-01:
(7*5)+(6*7)+(5*7)+(4*2)+(3*3)+(2*0)+(1*1)=130
130 % 10 = 0
So 57723-01-0 is a valid CAS Registry Number.
57723-01-0Relevant articles and documents
Discovering potent inhibitors against the β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of helicobacter pylori: Structure-based design, synthesis, bioassay, and crystal structure determination
He, Lingyan,Zhang, Liang,Liu, Xiaofeng,Li, Xianghua,Zheng, Mingyue,Li, HongLin,Yu, Kunqian,Chen, Kaixian,Shen, Xu,Jiang, Hualiang,Liu, Hong
experimental part, p. 2465 - 2481 (2010/03/03)
The discovery of HpFabZ inhibitors is now of special interest in the treatment of various gastric diseases. In this work, three series of derivatives (compounds 3, 4, and 5) were designed, synthesized, and their biological activities were investigated as potential HpFabZ inhibitors in a two phased manner. First, we designed and synthesized two series of derivatives (3a-r and 4a-u) and evaluated the enzyme-based assay against HpFabZ. Five compounds (3i-k, 3m, and 3q) showed potential inhibitory activity, with IC50 values less than 2 μM. Second, a focused combinatorial library containing 280 molecules was designed employing the LD1.0 program. Twelve compounds (5a-l) were selected and synthesized. The activity of the most potent compound 5h (IC 50) 0.86 μM) was 46 times higher than that of the hit 1. The high hit rate and the potency of the new HpFabZ inhibitors demonstrated the efficiency of the strategy for the focused library design and virtual screening.