57728-64-0

Basic information

• Product Name: 3-CHLORO-N-(2-HYDROXY-ETHYL)-BENZAMIDE
• Synonyms: 3-CHLORO-N-(2-HYDROXY-ETHYL)-BENZAMIDE;3-CHLORO-N-(2-HYDROXYETHYL)BENZENECARBOXAMIDE;Benzamide, 3-chloro-N-(2-hydroxyethyl)-
• CAS NO: 57728-64-0
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.63
• Mol File: 57728-64-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-CHLORO-N-(2-HYDROXY-ETHYL)-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-N-(2-HYDROXY-ETHYL)-BENZAMIDE(57728-64-0)
• EPA Substance Registry System: 3-CHLORO-N-(2-HYDROXY-ETHYL)-BENZAMIDE(57728-64-0)

Safety Data

• Hazardous Substances Data: 57728-64-0(Hazardous Substances Data)

Upstream product

• 1128-76-3 3-chloro-benzoic acid ethyl ester 
• 141-43-5 ethanolamine 
• 535-80-8 3-chlorobenzoate 
• 82891-77-8 2-(3-chlorophenyl)-4,5-dihydro-1,3-oxazole 
• 1644630-64-7 C₁₃H₇Cl₂NO₄ 
• 618-46-2 m-Chlorobenzoyl chloride 

Downstream Products

• 82891-78-9 2-Biphenyl-3-yl-4,5-dihydro-oxazole 
• 82891-90-5 2-(2-methyl-3-chlorophenyl)-2-oxazoline 
• 82891-81-4 2-(3-Propyl-phenyl)-4,5-dihydro-oxazole 
• 82891-80-3 2-(3-Ethyl-phenyl)-4,5-dihydro-oxazole 
• 82891-77-8 2-(3-chlorophenyl)-4,5-dihydro-1,3-oxazole 
• 15258-03-4 3-Chloro-N-(2-chloro-ethyl)-benzamide 

Relevant articles and documents

Mild, Selective Ru-Catalyzed Deuteration Using D2O as a Deuterium Source

A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl2(PPh3)3] and D2O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru-complexes under the given specific conditions.

Study of synthesis and cardiovascular activity of some furoxan derivatives as potential NO-donors

A series of hybrid molecules incorporating the furoxan and nicorandil moieties were designed as potential NO donors with cardiovascular and cerebrovascular activities. Thirty-six target molecules were successfully synthesized by conventional methods and characterized by infrared spectroscopy, 1H-NMR spectroscopy and high resolution mass spectra. The compounds were tested for their effects on KCl-induced contraction of rabbit thoracic aorta whose endothelium was denuded. Eight compounds were found to reduce KCl-induced contraction by more than 30% at 10 μM. All except one of these compounds are characterized by the presence of electron withdrawing groups in the phenyl ring attached via an amide or ester linkage to the furoxan moiety. The nature of the terminal carbonyl linkage (ester or amide) and the length or type of the alkyl chain bridging the two carbonyl functions have little effect on the activity. One of the active compounds, N-(4- methoxy-benzoyl)-N'-[3-methylfuroxanyl-4-carbonyl)piperazine (17i) was tested for hypotensive effects on anaesthetized rats at 1.5 mg/kg, and found to demonstrate a gradual and sustained hypotensive effect. The results suggest that the furoxannicorandil derivatives are a useful lead in the design of NO- donor compounds for hypertension.