577954-86-0 Usage
General Description
3'-Chloro-4'-fluoro-2-biphenylamine is a chemical compound typically used in the synthesis of pharmaceuticals and other organic compounds. Its molecular formula is C12H8ClF. 3'-Chloro-4'-fluoro-2-biphenylaMine belongs to the family of biphenyls and derivatives. These are organic compounds containing two benzene rings linked each other. The presence of the chlorine and fluorine atoms indicates that it is a halogenated biphenyl. Halogenated compounds are typically more reactive due to the presence of the highly electronegative halogen atoms, and this might make 3'-chloro-4'-fluoro-2-biphenylamine useful for certain types of chemical reactions. As with all chemicals, proper handling and storage are necessary to ensure safety.
Check Digit Verification of cas no
The CAS Registry Mumber 577954-86-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,7,7,9,5 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 577954-86:
(8*5)+(7*7)+(6*7)+(5*9)+(4*5)+(3*4)+(2*8)+(1*6)=230
230 % 10 = 0
So 577954-86-0 is a valid CAS Registry Number.
577954-86-0Relevant articles and documents
N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling
Lai, Mei-Jung,Lee, Hsueh-Yun,Chuang, Hsun-Yueh,Chang, Li-Hsun,Tsai, An-Chi,Chen, Mei-Chuan,Huang, Han-Lin,Wu, Yi-Wen,Teng, Che-Ming,Pan, Shiow-Lin,Liu, Yi-Min,Mehndiratta, Samir,Liou, Jing-Ping
, p. 6549 - 6558 (2015)
A series of N-sulfonyl-aminobiaryl derivatives have been examined as novel antitubulin agents. Compound 21 [N-(4′-cyano-3′-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonamide] exhibits remarkable antiproliferative activity against four cancer cell lines (pancreatic AsPC-1, lung A549, liver Hep3B, and prostate PC-3) with a mean GI50 value of 57.5 nM. Additional assays reveal that 21 inhibits not only tubulin polymerization but also the phosphorylation of STAT3 inhibition with an IC50 value of 0.2 μM. Four additional compounds (8, 10, 19, and 35) are also able to inhibit this phosphorylation. This study describes novel N-sulfonyl-aminobiaryl (biaryl-benzenesulfonamides) as potent anticancer agents targeting both STAT3 and tubulin. (Chemical Equation Presented).
