578-54-1 Usage
Description
2-Ethylaniline, also known as 2-ethylaniline, is a clear yellow to red-brownish liquid that turns brown upon exposure to air. It is insoluble in water and less dense than water, causing it to float on the surface. With a flash point of 185°F, it is known to be toxic through ingestion, inhalation, or skin absorption and may cause irritation to the skin, eyes, and mucous membranes.
Uses
Used in Pharmaceutical Industry:
2-Ethylaniline is used as an intermediate for the synthesis of various pharmaceutical products, contributing to the development of new medications and therapies.
Used in Dye Industry:
2-Ethylaniline serves as a reagent in the synthesis of bromoanthraquinones with different substituents, which are essential in producing novel dyes. This application is crucial for the development of innovative and vibrant colorants in various industries.
Used in Pesticide Industry:
As an intermediate, 2-Ethylaniline is utilized in the production of pesticides, playing a vital role in the development of effective and environmentally responsible pest control solutions.
Used in Synthesis of Phosphoinositide 3-Kinase Inhibitor:
2-Ethylaniline is employed in the optimization of phosphoinositide 3-kinase inhibitors, which are essential in the synthesis of various compounds and have potential applications in the pharmaceutical and chemical industries.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
2-Ethylaniline neutralizes acids in exothermic reactions to form salts plus water. May react with acids to release toxic fumes of aniline and oxides of nitrogen. Reacts violently with oxidizing materials. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Flammability and Explosibility
Notclassified
Safety Profile
: A poison. Moderately
toxic by ingestion. Flammable when
exposed to heat or flame; can react with
oxidizing materials. To fight fire, use foam,
CO2, dry chemical. When heated to
decomposition it emits highly toxic fumes of
aniline and NOx. See also NETHYLANILINE.
Potential Exposure
This material is used in making drugs,
dyes, and pesticides.
Shipping
UN2273 2-Ethylaniline, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials.
Incompatibilities
Combustible; vapor may form explosive
mixture with air above 80℃. Decomposes on contact with
light or air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, anhydrides, and chloroformates.
Contact with metals may evolve flammable hydrogen gas.
Check Digit Verification of cas no
The CAS Registry Mumber 578-54-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 578-54:
(5*5)+(4*7)+(3*8)+(2*5)+(1*4)=91
91 % 10 = 1
So 578-54-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H11N/c1-2-7-5-3-4-6-8(7)9/h3-6H,2,9H2,1H3
578-54-1Relevant articles and documents
Trapping Pd(0) in nanoparticle-assembled microcapsules: An efficient and reusable catalyst
Amali, Arlin Jose,Rana, Rohit Kumar
, p. 4165 - 4167 (2008)
Pd nanoparticles dually encased by soft (polyamine) and hard (silica) materials in a microcapsule structure, obtained via a nanoparticle self-assembly method, exhibit excellent catalytic activity, with efficient catalyst recovery and reusability. The Royal Society of Chemistry.
Hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis
-
Paragraph 0006; 0045-0048, (2021/07/31)
The invention relates to a hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis. According to the method, triethyl boron and potassium tert-butoxide are used as catalysts for the first time, and an aromatic nitro compound and pinacol borane which is low in price and easy to obtain can be conveniently catalyzed to be subjected to a hydroboration reduction reaction under mild conditions to prepare aromatic amine products. Compared with a traditional method, the method generally has the advantages that the catalyst is cheap and easy to obtain, operation is convenient, and reaction is safe. The selective hydroboration reduction reaction of the non-transition metal reagent catalyzed aromatic nitro compound and pinacol borane is realized for the first time, and a practical new reaction strategy is provided for laboratory preparation or industrial production of aromatic amine products.
Cobalt nanoclusters coated with N-doped carbon for chemoselective nitroarene hydrogenation and tandem reactions in water
Agostini, Giovanni,Calvino, Jose. J.,Corma, Avelino,Gutiérrez-Tarri?o, Silvia,Lopes, Christian W.,O?a-Burgos, Pascual,Rojas-Buzo, Sergio
supporting information, p. 4490 - 4501 (2021/06/28)
The development of active and selective non-noble metal-based catalysts for the chemoselective reduction of nitro compounds in aquo media under mild conditions is an attractive research area. Herein, the synthesis of subnanometric and stable cobalt nanoclusters, covered by N-doped carbon layers as core-shell (Co@NC-800), for the chemoselective reduction of nitroarenes is reported. TheCo@NC-800catalyst was prepared by the pyrolysis of the Co(tpy)2complex impregnated on Vulcan carbon. In fact, the use of a molecular complex based on six N-Co bonds drives the formation of a well-defined and distributed cobalt core-shell nanocluster covered by N-doped carbon layers. In order to elucidate its nature, it has been fully characterized by using several advanced techniques. In addition, this as-prepared catalyst showed high activity, chemoselectivity and stability toward the reduction of nitro compounds with H2and under mild reaction conditions; water was used as a green solvent, improving the previous results based on cobalt catalysts. Moreover, theCo@NC-800catalyst is also active and selective for the one-pot synthesis of secondary aryl amines and isoindolinones through the reductive amination of nitroarenes. Finally, based on diffraction and spectroscopic studies, metallic cobalt nanoclusters with surface CoNxpatches have been proposed as the active phase in theCo@NC-800material.