57817-03-5

Basic information

• Product Name: 6-Fluoro-7-Methyl Isatin
• Synonyms: 1H-Indole-2,3-dione, 6-fluoro-7-Methyl-;6-fluoro-7-methylindoline-2,3-dione;skln-0002
• CAS NO: 57817-03-5
• Molecular Formula: C₉H₆FNO₂
• Molecular Weight: 179.15
• Mol File: 57817-03-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 204-206 °C
• Appearance: /
• Density: 1.399 g/cm³
• Refractive Index: 1.574
• PKA: 8.87±0.20(Predicted)
• CAS DataBase Reference: 6-Fluoro-7-Methyl Isatin(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-7-Methyl Isatin(57817-03-5)
• EPA Substance Registry System: 6-Fluoro-7-Methyl Isatin(57817-03-5)

Safety Data

• Hazardous Substances Data: 57817-03-5(Hazardous Substances Data)

Usage

General Description

6-Fluoro-7-Methyl Isatin is a chemical compound with the molecular formula C9H6FNO2. It is an isatin derivative that contains a fluorine atom at the 6-position and a methyl group at the 7-position of the isatin ring. 6-Fluoro-7-Methyl Isatin is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also known for its potential biological activities, including antifungal, antibacterial, and antiviral properties. Additionally, 6-Fluoro-7-Methyl Isatin has been studied for its potential use in the development of new drug candidates for the treatment of various diseases and infections.

InChI:InChI=1/C9H6FNO2/c1-4-6(10)3-2-5-7(4)11-9(13)8(5)12/h2-3H,1H3,(H,11,12,13)

Upstream product

• 443-86-7 3-fluoro-2-methylaniline 
• 114895-95-3 3-fluoro-2-methyl-α-isonitrosoacetanilide 
• 302-17-0 chloral hydrate 
• 654-20-6 3-fluoro-2-methyl aniline hydrochloride 

Downstream Products

• 129833-28-9 2-amino-4-fluoro-3-methylbenzoic acid 
• 526-55-6 2-(3-indole)-ethanol 
• 1415597-14-6 2-amino-5-chloro-4-fluoro-3-methylbenzaldehyde 
• 1415597-12-4 2-amino-5-chloro-4-fluoro-3-methylbenzoic acid 
• 1415597-13-5 (2-amino-5-chloro-4-fluoro-3-methylphenyl)methanol 
• 129833-44-9 2-(2-Carboxymethyl-phenoxy)-4-fluoro-3-methyl-benzoic acid 
• 129833-35-8 4-fluoro-2-iodo-3-methylbenzoic acid 

Relevant articles and documents

PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT FACTOR D MEDICAL DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement factor D or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade. The inhibitors of factor D described herein reduce the excessive activation of complement.

Potential Antitumor Agents. 61. Structure-Activity Relationships for in Vivo Colon 38 Activity among Disubstituted 9-Oxo-9H-xanthene-4-acetic Acids

Analogues of 9-oxo-9H-xanthene-4-acetic acid (XAA) bearing small, lipophilic 5-substituents are among the most dose-potent compounds yet reported with the capability of causing hemorrhagic necrosis of implanted colon 38 tumors in mice.To further extend structure-activity relationships among this class of compound, a series of XAA derivatives bearing two small lipophilic groups at various positions have been prepared and evaluated.The 5,6-disubstituted compounds in particular show consistently high levels of both dose potency and activity, suggesting this is the optimal configuration among substituted 9-oxo-9H-xanthene-4-acetic acids.The 5,6-dimethyl and 5-methyl-6-methoxy are the most effective analogues, showing in vivo colon 38 activity comparable to that of FAA at 10-15-fold lower doses and superior activity to FAA at the respective optimal doses, and the former has been selected for detailed evaluation.