57843-53-5

Basic information

• Product Name: N,N,N',N'-tetrakis(2-hydroxypropyl)adipamide
• Synonyms: N,N,N',N'-tetrakis(2-hydroxypropyl)adipamide;n,n,n',n'-tetrakis(2-hydroxypropyl)-hexanediamid;N,N,N',N'-tetrakis(2-Hydroxypropyl)hexanediamide;N,N,N',N'-tetrakis(2-hydroxypropyl)-Hexanediamide;N,N,N',N'-Tetrakis(2-hydroxypropyl)hexanebisamide;Einecs 260-982-3;Hexanediamide, N,N,N',N'-tetrakis(2-hydroxypropyl)-;Hexanediamide, N1,N1,N6,N6-tetrakis(2-hydroxypropyl)-
• CAS NO: 57843-53-5
• Molecular Formula: C₁₈H₃₆N₂O₆
• Molecular Weight: 376.48824
• EINECS: 260-982-3
• Mol File: 57843-53-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.16[at 20℃]
• Vapor Pressure: 0.005Pa at 25℃
• Water Solubility: 612g/L at 20℃
• CAS DataBase Reference: N,N,N',N'-tetrakis(2-hydroxypropyl)adipamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N,N',N'-tetrakis(2-hydroxypropyl)adipamide(57843-53-5)
• EPA Substance Registry System: N,N,N',N'-tetrakis(2-hydroxypropyl)adipamide(57843-53-5)

Safety Data

• Hazardous Substances Data: 57843-53-5(Hazardous Substances Data)

Usage

Flammability and Explosibility

Nonflammable

Synthetic route

hexanedioic acid dimethyl ester (627-93-0) + diisopropanolamine (110-97-4) → N,N,N',N'-tetrakis(β-hydroxypropyl)adipamide (57843-53-5)

Conditions	Yield
Stage #1: diisopropanolamine With potassium methanolate at 100℃; for 1h; Green chemistry; Stage #2: hexanedioic acid dimethyl ester for 2h; Reagent/catalyst; Green chemistry;	89.8%
With potassium methanolate at 100℃; for 4h; Reagent/catalyst;	157.3 g

Upstream product

• 627-93-0 hexanedioic acid dimethyl ester 
• 110-97-4 diisopropanolamine 

Relevant articles and documents

Method for preparing N, N, N

The method comprises the following steps: (N) adding an excess of diisopropanolamine and an alkaline catalyst into a reaction kettle, then dropwise adding dimethyl adipate N, and preparing N, 1, N N (2): The temperature in the reaction kettle was decreased to the set temperature, and the neutralized acid was added dropwise or batchwise to the reaction kettle under a vacuum condition to neutralize excess diisopropanolamine, and dehydration was performed simultaneously. (3): After completion of the neutralization, a solvent was added to the reaction kettle, and the crystals were stirred and then filtered to separate the diisopropanolamine sulfate. The filtrate was separated off by distillation to give a high purity N, N, NTo the method, unreacted diisopropanolamine raw materials are separated through the high-amine ester, the preparation process is simple, the energy consumption is low, and the separated diisopropanolamine salt can be recycled as an industrial raw material.

Preparation method of N,N,N,N'-tetra(beta-hydroxypropyl)adipamide

The invention discloses a preparation method of N,N,N,N'-tetra(beta-hydroxypropyl)adipamide, which includes steps of: 1) adding diisopropanol amine, in excessive amount, and an alkaline catalyst to areaction kettle, heating the reaction kettle to 100 +/- 5 DEG C, adding dimethyl adipate, and preparing a N,N,N,N'-tetra(beta-hydroxypropyl)adipamide crude product under vacuum; 2) cooling the N,N,N,N'-tetra(beta-hydroxypropyl)adipamide crude product to preset temperature and adding the dimethyl adipate, and stirring and crystallizing the product; 3) after the crystallization, adding a co-dispersant and fully stirring the product, and at crystalline temperature, performing positive pressure filtration on the crystal slurry to separate a filter cake and a filtrate, and drying the filter cake toobtain a high-purity product. The method can be used for preparing the high-purity N,N,N,N'-tetra(beta-hydroxypropyl)adipamide product at high yield. The solvent is high in boiling point and flash point; so that the crystalline process, compared with a conventional solvent system, is safe and environment-friendly.