57928-96-8

Basic information

• Product Name: 4-(2-hydroxyethoxy)benzonitrile
• Synonyms: 4-(2-hydroxyethoxy)benzonitrile;UKRORGSYN-BB BBV-076375
• CAS NO: 57928-96-8
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• Mol File: 57928-96-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 87.5 °C(Solv: benzene (71-43-2))
• Boiling Point: 345.9±17.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 14.18±0.10(Predicted)
• CAS DataBase Reference: 4-(2-hydroxyethoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-hydroxyethoxy)benzonitrile(57928-96-8)
• EPA Substance Registry System: 4-(2-hydroxyethoxy)benzonitrile(57928-96-8)

Safety Data

• Hazardous Substances Data: 57928-96-8(Hazardous Substances Data)

Usage

General Description

4-(2-hydroxyethoxy)benzonitrile, also known as HG-531, is a chemical compound commonly used as a UV absorber in various personal care and cosmetic products, as well as in plastics and adhesives. It belongs to the class of phenyl benzonitriles and is a colorless to pale yellow liquid. It is known for its ability to absorb UV light and protect products from photodegradation caused by sun exposure. This makes it a valuable ingredient in sunscreen, moisturizers, and other sun care products. Additionally, it has also been used as a stabilizer in plastics and adhesives to prevent degradation from UV exposure. However, there are some concerns about its potential health risks, and it is important to use products containing this chemical in a safe and controlled manner.

Upstream product

• 96-49-1 [1,3]-dioxolan-2-one 
• 767-00-0 4-cyanophenol 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 
• 3328-57-2 sodium 4-cyanophenolate 
• 75-21-8 oxirane 
• 141-52-6 sodium ethanolate 

Downstream Products

• 57323-80-5 4-(2-hydroxy-ethoxy)-benzamidine 
• 1412334-24-7 C₂₅H₃₁NO₅ 
• 1412334-19-0 C₁₂H₁₅NO₂ 
• 1095130-53-2 C₁₂H₁₁NO₂ 
• 710334-15-9 N-[4-(2-hydroxy-ethoxy)-benzyl]-3,5-dimethyl-benzamide 
• 182964-58-5 2-[4-(aminomethyl)phenoxy]ethanol 

Relevant articles and documents

Revisiting Hydroxyalkylation of Phenols with Cyclic Carbonates

Described is a tetrabutylammonium fluoride-mediated hydroxyalkylation reaction of phenols with cyclic carbonates. This operationally simple method enables the synthesis of a variety of aryl β-hydroxyethyl ethers in good to excellent yields with a very small amount of catalyst loading (0.1–1 mol%). Of particular note is the efficient conversion of aromatic diols and phloroglucinol to the corresponding bis- and tris-hydroxyethylated products. To further showcase the versatility of this protocol, guaifenesin was prepared with a single step by the condensation of guaiacol and glycerol carbonate. We also developed a flow ethoxylation process permitting the continuous synthesis of multiflorol. (Figure presented.).

Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ inhibitors

The emergence and spread of multidrug-resistant strains of the human pathological bacteria are generating a threat to public health worldwide. In the current study, a series of PC190723 derivatives was synthesized and investigated for their antimicrobial activity. The compounds exhibited good activity against several Gram-positive bacteria as determined by comparison of diameters of the zone of inhibition of test compounds and standard antibiotics. Compound 9 with a fluorine substitution on the phenyl ring showed the best antibacterial activity in the series against M. smegmatis with the zone ratio of 0.62, and against S. aureus with the zone ratio of 0.44. The results from this study indicate that based on the unique 3-methoxybenzamide pharmacophore, compound 9 may represent a promising lead candidate against Gram-positive bacteria that are worthy of further investigation

The inhibition of monoamine oxidase by 8-(2-phenoxyethoxy)caffeine analogues

Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an IC 50 value of 0.383M towards MAO-B. In an attempt to improve on the inhibition potency of this compound and to discover highly potent reversible MAO-B inhibitors, in the present study, a series of 8-(2-phenoxyethoxy)caffeine analogues containing various substituents on C4 of the phenoxy ring, were synthesized and evaluated as inhibitors of human MAO-A and -B. The results show that the 8-(2-phenoxyethoxy)caffeine analogues are selective and reversible MAO-B inhibitors with the most potent homologue, 8-{2-[4-(trifluoromethyl) phenoxy]ethoxy}caffeine, exhibiting an IC50 value of 0.061μM. These highly potent inhibitors are useful leads in the design of therapies for neurodegenerative disorders such as Parkinsons disease. Georg Thieme Verlag KG Stuttgart New York.