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58-20-8

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58-20-8 Usage

Description

Testosterone cypionate is an anabolic steroid that is classified as a male hormone (androgen). Testosterone cypionate is an injectable solution whose brand name is Depo-testosterone. The generic drug is administered to enhance performance in athletics and bodybuilding, and as a prescription drug that alleviates the symptoms of hypogonadism in men. In most cases, the drug is administered to the muscle or the subcutaneous layer of the skin through an injection based on clinical indications or once every few weeks. The androgenic/anabolic structure of Testosterone cypionate has a score of 100, which makes it an appropriate steroid for strength and size associated gains. Testosterone cypionate influences changes in the size, shape, number, and appearance of muscle fibers.

Mechanism of Action

In humans, the influence of testosterone may take place based on two mechanisms: through alteration of the hormone to estradiol and trigger specific estrogen receptors, and by triggering of the androgen receptor. Free testosterone (T) is transmitted to the cytoplasm of selected cells for attachment with the androgen receptor, or diminution to 5α-dihydrotestosterone (DHT) through the cytoplasmic enzyme 5α-reductase. DHT creates a strong bond with a similar androgen receptor, one that is stronger than free testosterone to enhance its androgenic potency. The DHT-receptor or the T-receptor undergoes structural modifications that allow its free flow into the nucleus of the cell for binding with certain nucleotide sequences particular to the chromosomal DNA. Notably, these binding spots are referred to as hormone response elements (HREs), and their effect on the transcriptional activity of specific genes results in the androgenic effects. When Testosterone cypionate is absorbed into the body, the drug is processed in the blood and 40% of the resultant testosterone binds with plasma globulin, the remaining 2% either binds with proteins such as albumin or it remains unbound.

Information on Dosing

The dosage requirements of Testosterone cypionate are dependent on an individual’s age, the need for testosterone therapy, the intensity of the condition, additional medical conditions and one’s reaction after injection of the first dose. For primary hypogonadism and hypogonadotropic hypogonadism, 50-400mg is injected into one’s gluteal muscle every 2-4weeks. The administration of Testosterone cypionate to enhance performance may necessitate a weekly injection of the hormone, where two smaller injections could be more effective. Noteworthy, multiple injections ensure that an individual’s blood levels are at a peak, which mitigates the effects of performance level dosage instructions. In this case, the administration of smaller doses of the hormone may range from 200mg-1000mg per week, which is solely dependent on an individual’s needs.

Interactions

Testosterone cypionate can interact with herbs, vitamins and other medications that one may be taking. Such interactions may inhibit the appropriate functionality of the drug hence to avoid this, it is advisable to consult a doctor for management of medications. Notably, some of the drug interactions may include oral blood thinners, adrenocorticotropic and corticosteroid hormones, oral diabetes drugs and insulin.

Indications

In men, Testosterone cypionate is indicated for primary or secondary hypogonadism. The testosterone cypionate injection should only be used to treat specific symptoms of testosterone deficiency. Before the initiation of Testosterone cypionate treatment, testosterone deficiency should be validated by clinical features and biochemical assays.

Contraindications

Testosterone cypionate is contradicted in persons who have known or suspected breast and testicular carcinomas. If one is allergic to testosterone they should refrain from the use of Testosterone cypionate. Females should keep off the drug especially if one is either breastfeeding or pregnant.

Side Effects

The common side effects associated with testosterone cypionate include headaches, mood swings, erections which last longer than normal, frequent erections, gynecomastia, hair growth, pain and swelling at the point of injection, acne, retention of excess water, and a reduction of the sperm count when one indulges in high dosages of the drug. Serious side effects of testosterone cypionate use include aromatization, heart attack, stroke, prostate cancer, liver problems, deep vein thrombosis, pulmonary embolism, polycythemia, and enlargement of the prostate gland. Testosterone cypionate is well-tolerated amongst most men hence the common side effects can be controlled easily while the serious side effects are not guaranteed.

Testosterone Cypionate Warnings

Before administering Testosterone cypionate, one should take into consideration the fact that people with liver problems may experience liver damage, people with heart and kidney problems may experience water and salt retention. For people with breast cancer, prostate cancer, sleep apnea, polycythemia, high cholesterol levels and blood clots, Testosterone cypionate may amplify their respective conditions. It is not advisable for seniors above the age of 65 to take Testosterone cypionate as it may increase their chances of contracting prostate cancer, heart disease or an enlarged prostate. The drug should only be used by males.

Originator

Depo-Testosterone,Upjohn,US,1951

Uses

Testosterone Cypionate is an anabolic steroid with androgenic properties. Testosterone Cypionate is used for testosterone therapy in males with hypogonadism. Controlled Substance.

Manufacturing Process

1 g of crude 3-enol-ethyl ether of testosterone dissolved in 3 cc of pyridine is treated with 2 cc of β-cyclopentylpropionic anhydride (obtained from the β- cyclopentylpropionic acid and acetic anhydride: boiling point 180°C/2 mm Hg). After standing at room temperature overnight the mixture is diluted with water and extracted with ether, the ethereal layer, washed with water to neutrality and dried, is evaporated by vacuum. The oily residue is taken up in petroleum ether and filtered through a layer of aluminum oxide, which is afterwards washed with a further amount of petroleum ether. The solution so filtered and purified is evaporated to dryness; the crystalline residue is recrystallized from a small amount of methanol containing a trace of pyridine: about 1 g of 3-enol-ethyl-ether of the β-cyclopentyl propionate of testosterone, melting point 86°C to 88°C, is so obtained (by further recrystallization melting point 90°C to 91°C). This product (that may be employed either in the crystalline state, or in the oily one, that is, before the purification by filtration through aluminum oxide) by treatment with a small amount of hydrochloric acid in acetone solution yields the β-cyclopentyl propionate of testosterone, melting point 99°C to 101°C (recrystallized from methanol).

Therapeutic Function

Androgen

Veterinary Drugs and Treatments

The use of injectable esters of testosterone in veterinary medicine is limited primarily to its use in dogs (and perhaps cats) for the treatment of testosterone-responsive urinary incontinence in neutered males. Testosterone has been used to treat a rare form of dermatitis (exhibited by bilateral alopecia) in neutered male dogs. These drugs are also used in bovine medicine to produce an estrus-detector (teaser) animal in cull cows, heifers, and steers. The effectiveness of testosterone to increase libido, treat hypogonadism, aspermia, and infertility in domestic animals has been disappointing.

Check Digit Verification of cas no

The CAS Registry Mumber 58-20-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 58-20:
(4*5)+(3*8)+(2*2)+(1*0)=48
48 % 10 = 8
So 58-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H40O3/c1-26-15-13-20(28)17-19(26)8-9-21-22-10-11-24(27(22,2)16-14-23(21)26)30-25(29)12-7-18-5-3-4-6-18/h17-18,21-24H,3-16H2,1-2H3/t21-,22-,23-,24-,26-,27-/m0/s1

58-20-8 Well-known Company Product Price

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  • (1647001)  Testosterone cypionate  United States Pharmacopeia (USP) Reference Standard

  • 58-20-8

  • 1647001-200MG

  • 5,736.51CNY

  • Detail

58-20-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Testosterone cypionate

1.2 Other means of identification

Product number -
Other names depo-testosterone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58-20-8 SDS

58-20-8Synthetic route

cyclopentanepropanoyl chloride
104-97-2

cyclopentanepropanoyl chloride

testosterone
58-22-0

testosterone

testosterone cypionate
58-20-8

testosterone cypionate

Conditions
ConditionsYield
With pyridine In N,N-dimethyl acetamide at 0 - 20℃; for 5h; Inert atmosphere;77%
testosterone
58-22-0

testosterone

3-cyclopentyl-propionic acid-anhydride
58032-37-4

3-cyclopentyl-propionic acid-anhydride

testosterone cypionate
58-20-8

testosterone cypionate

17β-(3-cyclopentyl-propionyloxy)-androst-5-en-3β-ol

17β-(3-cyclopentyl-propionyloxy)-androst-5-en-3β-ol

testosterone cypionate
58-20-8

testosterone cypionate

Conditions
ConditionsYield
With lithium tetra(iso-propoxo)aluminate; cyclohexanone
3-ethoxy-17β-(3-cyclopentyl-propionyloxy)-androsta-3,5-diene
56736-66-4

3-ethoxy-17β-(3-cyclopentyl-propionyloxy)-androsta-3,5-diene

testosterone cypionate
58-20-8

testosterone cypionate

Conditions
ConditionsYield
With hydrogenchloride; acetone
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

testosterone cypionate
58-20-8

testosterone cypionate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid anhydride
View Scheme
Multi-step reaction with 3 steps
1: acetic acid anhydride
3: aqueous HCl; acetone
View Scheme
3-cyclopentyl-propionic acid-anhydride
58032-37-4

3-cyclopentyl-propionic acid-anhydride

testosterone cypionate
58-20-8

testosterone cypionate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: aqueous HCl; acetone
View Scheme
17-hydroxy-3-oxo-androst-4-ene-17-carbonitrile
17006-07-4, 38394-98-8, 77881-13-1

17-hydroxy-3-oxo-androst-4-ene-17-carbonitrile

testosterone cypionate
58-20-8

testosterone cypionate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Edukt 1: aus Androst-4-en-3,17-dion
View Scheme
testosterone cypionate
58-20-8

testosterone cypionate

testosterone
58-22-0

testosterone

Conditions
ConditionsYield
With water In methanol at 40℃; Rate constant; pH 9, also reaction in the presence of 2-hydroxypropyl-β-cyclodextrin;
In ethanol; water at 37℃; Product distribution; Hydrolysis;
With Novozyme 51032 In aq. phosphate buffer at 20℃; for 20h; pH=8; Enzymatic reaction;
2,2,3,3,3-pentafluoropropanoic anhydride
356-42-3

2,2,3,3,3-pentafluoropropanoic anhydride

testosterone cypionate
58-20-8

testosterone cypionate

2,2,3,3,3-Pentafluoro-propionic acid (8R,9S,10R,13S,14S,17S)-17-(3-cyclopentyl-propionyloxy)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

2,2,3,3,3-Pentafluoro-propionic acid (8R,9S,10R,13S,14S,17S)-17-(3-cyclopentyl-propionyloxy)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
at 70℃; for 0.25h;
N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide
24589-78-4

N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide

testosterone cypionate
58-20-8

testosterone cypionate

3-Cyclopentyl-propionic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-trimethylsilanyloxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

3-Cyclopentyl-propionic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-trimethylsilanyloxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
With ammonium iodide; 1,4-dithio-erythritol at 60℃; for 0.25h;
testosterone cypionate
58-20-8

testosterone cypionate

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

3-Cyclopentyl-propionic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-(2,2,2-trifluoro-acetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

3-Cyclopentyl-propionic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-(2,2,2-trifluoro-acetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
at 70℃; for 0.25h;
testosterone cypionate
58-20-8

testosterone cypionate

heptafluorobutyric anhydride
336-59-4

heptafluorobutyric anhydride

2,2,3,3,4,4,4-Heptafluoro-butyric acid (8R,9S,10R,13S,14S,17S)-17-(3-cyclopentyl-propionyloxy)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

2,2,3,3,4,4,4-Heptafluoro-butyric acid (8R,9S,10R,13S,14S,17S)-17-(3-cyclopentyl-propionyloxy)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
at 70℃; for 0.25h;

58-20-8Downstream Products

58-20-8Relevant articles and documents

Method for synthesizing alkyl-acid testosterone compound

-

Paragraph 0051; 0052; 0053; 0054, (2016/10/10)

The invention provides a method for synthesizing an alkyl-acid testosterone compound. The method comprises the step of subjecting a testosterone compound to the esterification reaction with the presence of a solvent and an alkali to obtain an alkyl-acid testosterone compound. According to the technical scheme of the method for synthesizing the alkyl-acid testosterone compound, the solvent is a water-soluble organic solvent. Therefore, after the reaction, the obtained product can be precipitated through adding water, so that the overall process is simplified.

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