58012-09-2

Basic information

• Product Name: 8-(3-phenothiazin-10-yl-propyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
• CAS NO: 58012-09-2
• Molecular Weight: 470.638
• Mol File: 58012-09-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-(3-phenothiazin-10-yl-propyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(3-phenothiazin-10-yl-propyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one(58012-09-2)
• EPA Substance Registry System: 8-(3-phenothiazin-10-yl-propyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one(58012-09-2)

Safety Data

• Hazardous Substances Data: 58012-09-2(Hazardous Substances Data)

Upstream product

• 92-84-2 10H-phenothiazine 
• 5909-59-1 10-(3-chloropropyl)-10H-phenothiazine 
• 1021-25-6 1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 

Relevant articles and documents

Identification of a non peptidic RANTES antagonist

A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50 = 3 μM) was found to inhibit specific binding of 125I-RANTES, but not 125I-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells.