5823-51-8

Basic information

• Product Name: [1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE
• Synonyms: [1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE
• CAS NO: 5823-51-8
• Molecular Formula: C₂H₆N₂O₂S
• Molecular Weight: 122.14624
• Mol File: 5823-51-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 171-172 °C
• Boiling Point: 376.2°C at 760 mmHg
• Flash Point: 181.3°C
• Appearance: /
• Density: 1.398
• Vapor Pressure: 3.41E-06mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.39±0.20(Predicted)
• CAS DataBase Reference: [1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: [1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE(5823-51-8)
• EPA Substance Registry System: [1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE(5823-51-8)

Safety Data

• Hazardous Substances Data: 5823-51-8(Hazardous Substances Data)

Usage

General Description

[1,2,5]Thiadiazolidine 1,1-Dioxide is a chemical compound from the group of organosulfur compounds. This chemical belongs to the category of a heterocyclic compound, signifying the presence of atoms of at least two different elements in its rings. The thiadiazolidine ring structure features nitrogen, sulfur, and carbon atoms. Its unique structure allows for a variety of chemical interactions making it potentially useful in different chemical, industrial, and pharmaceutical applications. Like many chemical compounds, careful handling and usage of [1,2,5]Thiadiazolidine 1,1-Dioxide is needed due to potential risks and hazards.

InChI:InChI=1/C7H6N2O/c8-4-5-3-6(9)1-2-7(5)10/h1-3,10H,9H2

Upstream product

• 7803-58-9 SULFAMIDE 
• 107-15-3 ethylenediamine 
• 144432-72-4 2-benzyl-1,2,5-thiadiazolidine 1,1-dioxide 
• 67104-91-0 2,5-di-tert-butyl-[1,2,5]thiadiazolidine 1,1-dioxide 

Downstream Products

• 1092980-94-3 C₈H₈FN₃O₄S 
• 1237802-47-9 C₂₃H₂₃F₅N₂O₅S₂ 

Relevant articles and documents

Discovery of New Imidazo[2,1- b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising in Vitro and in Vivo Anti-melanoma Activity

BRAF is an important component of MAPK cascade. Mutation of BRAF, in particular V600E, leads to hyperactivation of the MAPK pathway and uncontrolled cellular growth. Resistance to selective inhibitors of mutated BRAF is a major obstacle against treatment of many cancer types. In this work, a series of new (imidazo[2,1-b]thiazol-5-yl)pyrimidine derivatives possessing a terminal sulfonamide moiety were synthesized. Pan-RAF inhibitory effect of the new series was investigated, and structure-activity relationship is discussed. Antiproliferative activity of the target compounds was tested against the NCI-60 cell line panel. The most active compounds were further tested to obtain their IC50 values against cancer cells. Compound 27c with terminal open chain sulfonamide and 38a with a cyclic sulfamide moiety showed the highest activity in enzymatic and cellular assay, and both compounds were able to inhibit phosphorylation of MEK and ERK. Compound 38a was selected for testing its in vivo activity against melanoma. Cellular and animal activities are reported.

Carbazole-Containing Sulfonamides as Cryptochrome Modulators

The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.

Synthesis and Biological Activity of 3--5--1H-indole and Analogues: Agonists for the 5-HT1D Receptor

A novel series of 5-(1,1-dioxo-1,2,5-thiadiazolidin-2-yl)tryptamines was designed, synthesized, and evaluated as 5-HT1D receptor agonists.Compounds such as 8d,f,k were identified which had comparable affinity, potency, and receptor selectivity