582316-00-5 Usage
General Description
Z-Val-DL-Asp-fluoromethylketone is a specific type of chemical compound known for its role in medical and biological research. It is a crucial component in the field of biochemistry, often used as a potent inhibitor in the process of caspase family cysteine proteases. These proteases play a crucial role in apoptosis, which is programmed cell death. Its work as an inhibitor helps us to have a better understanding of cellular processes and disease treatments. However, this compound and its effects require careful handling due to its high reactivity. Precise controlled researches are necessary to fully understand its biological and therapeutic values.
Check Digit Verification of cas no
The CAS Registry Mumber 582316-00-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,8,2,3,1 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 582316-00:
(8*5)+(7*8)+(6*2)+(5*3)+(4*1)+(3*6)+(2*0)+(1*0)=145
145 % 10 = 5
So 582316-00-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H23FN2O6/c1-11(2)16(17(25)20-13(8-15(23)24)14(22)9-19)21-18(26)27-10-12-6-4-3-5-7-12/h3-7,11,13,16H,8-10H2,1-2H3,(H,20,25)(H,21,26)(H,23,24)/t13?,16-/m0/s1
582316-00-5Relevant articles and documents
Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid
Wang, Yan,Huang, Jin-Chen,Zhou, Zhang-Lin,Yang, Wu,Guastella, John,Drewe, John,Cai, Sui Xiong
, p. 1269 - 1272 (2007/10/03)
This article describes the synthesis and biological evaluation of a series of dipeptidyl aspartyl fluoromethylketones as caspase-3 inhibitors. Structure-activity relationship (SAR) studies showed that for caspase-3 inhibition, Val is the best P2 amino acid. The SAR studies also showed that the Asp free carboxylic acid in P1 is important for caspase inhibiting activities, as well as for selectivity over other proteases.
