5832-01-9

Basic information

• Product Name: 5-NITROTHIOPHENE-2-CARBOXYLICMETHYLESTER
• Synonyms: 5-NITROTHIOPHENE-2-CARBOXYLICMETHYLESTER;5-Nitro-2-thiophenecarboxylic acid methyl ester;5-Nitrothiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 5-nitro-, Methyl ester;Methyl 5-Nitro-2-thiophenecarboxylate;5-Nitro-2-thiophenecarboxylic acid methyl 98%;5-Nitro-2-thiophenecarboxylic acid methyl;Methyl 5-Nitro-2-thiophen
• CAS NO: 5832-01-9
• Molecular Formula: C₆H₅NO₄S
• Molecular Weight: 187.17
• EINECS: 227-412-5
• Mol File: 5832-01-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 99 °C
• Boiling Point: 306.9 °C at 760 mmHg
• Flash Point: 139.4 °C
• Appearance: /
• Density: 1.454 g/cm³
• Vapor Pressure: 0.000751mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-NITROTHIOPHENE-2-CARBOXYLICMETHYLESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITROTHIOPHENE-2-CARBOXYLICMETHYLESTER(5832-01-9)
• EPA Substance Registry System: 5-NITROTHIOPHENE-2-CARBOXYLICMETHYLESTER(5832-01-9)

Safety Data

• Hazardous Substances Data: 5832-01-9(Hazardous Substances Data)

Usage

General Description

5-Nitrothiophene-2-carboxylicmethyl ester is a chemical compound with the molecular formula C7H5NO4S. It is a yellow crystalline solid that is commonly used in the synthesis of pharmaceuticals and agrochemicals. 5-NITROTHIOPHENE-2-CARBOXYLICMETHYLESTER is classified as a nitro compound due to the presence of a nitro group, and it is also a type of ester, containing a carboxylmethyl ester functional group. 5-Nitrothiophene-2-carboxylicmethyl ester is known for its diverse reactivity and has been studied for its potential biological and pharmacological activities. It is important to handle this compound with care due to its potential hazards, and it should be used in a controlled laboratory setting by trained professionals.

InChI:InChI=1/C6H5NO4S/c1-11-6(8)4-2-3-5(12-4)7(9)10/h2-3H,1H3

Upstream product

• 67-56-1 methanol 
• 6317-37-9 5-nitrothiophene-2-carboxylic acid 
• 186581-53-3 diazomethane 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 77-78-1 dimethyl sulfate 
• 527-72-0 2-thiophenylcarboxylic acid 
• 39978-57-9 5-nitrothiophene-2-carbonyl chloride 
• 4521-33-9 5-nitro-2-thiophenecarboxaldehyde 
• 107-06-2 1,2-dichloro-ethane 
• 74-88-4 methyl iodide 
• 14289-24-8 5-nitrothiophene-2-carboxaldehyde diacetate 
• 63011-97-2 2-thiophenecarboxaldehyde diacetate 
• 7647-01-0 hydrogenchloride 
• 16689-02-4 5-nitro-2-thienyl cyanide 

Downstream Products

• 75735-47-6 5-nitro-4-methyl-2-methoxycarbonylthiophen 
• 1314091-79-6 C₁₉H₁₆N₂O₅S 
• 1314091-77-4 methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate 
• 1314091-75-2 C₁₃H₁₂N₂O₅S 
• 1314091-73-0 C₁₃H₉F₃N₂O₄S 
• 1314091-72-9 C₁₃H₉F₃N₂O₄S 
• 1314091-71-8 C₁₃H₉F₃N₂O₅S 
• 1314091-70-7 C₁₃H₉F₃N₂O₅S 
• 1314091-69-4 C₁₃H₁₂N₂O₄S 
• 1314091-67-2 C₁₃H₁₂N₂O₄S 
• 1314092-14-2 methyl 5-(3-cyano-2-nitrophenylamino)thiophene-2-carboxylate 
• 1314092-12-0 C₁₂H₉ClN₂O₄S 
• 1314092-10-8 C₁₂H₉ClN₂O₄S 
• 1314091-63-8 methyl 5-(3-fluoro-2-nitrophenylamino)thiophene-2-carboxylate 

Relevant articles and documents

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Optimization of potent inhibitors of P. falciparum dihydroorotate dehydrogenase for the treatment of malaria

Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum is unable to salvage pyrimidines and must rely on de novo biosynthesis for survival. We report herein the synthesis and structure-activity relationship of a series of 5-(2-methylbenzimidazol-1-yl)-N-alkylthiophene-2-carboxamides that are potent inhibitors against PfDHODH but do not inhibit the human enzyme. On the basis of efficacy observed in three mouse models of malaria, acceptable safety pharmacology risk assessment and safety toxicology profile in rodents, lack of potential drug-drug interactions, acceptable ADME/pharmacokinetic profile, and projected human dose, 5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl) -N-cyclopropylthiophene-2-carboxamide 2q was identified as a potential drug development candidate.

Novel compounds useful for bradykinin B1 receptor antagonism

Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor.