58337-16-9 Usage
General Description
ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE is a specialized organic compound characterized by its unique structure and properties. It is primarily distinguished by its formation featuring an ethyl ester, an aniline (a compound derived from ammonia), and a furancarboxylate, which is a heterocyclic compound. This particular compound appears in the context of in-depth chemical research, pharmaceutical development, or industrial applications. The nature and effects of ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE on biological systems, its potential uses, and safety considerations are typically determined through rigorous scientific testing and analysis. Like many such specialized chemical compounds, its handling and application should be done with care while adhering to established safety protocols.
Check Digit Verification of cas no
The CAS Registry Mumber 58337-16-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,3,3 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 58337-16:
(7*5)+(6*8)+(5*3)+(4*3)+(3*7)+(2*1)+(1*6)=139
139 % 10 = 9
So 58337-16-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H13NO4/c1-2-17-13(16)11-10(15)8-18-12(11)14-9-6-4-3-5-7-9/h3-7,14H,2,8H2,1H3
58337-16-9Relevant articles and documents
Synthesis, design, and structure–activity relationship of the pyrimidone derivatives as novel selective inhibitors of plasmodium falciparum dihydroorotate dehydrogenase
Xu, Le,Li, Wenjie,Diao, Yanyan,Sun, Hongxia,Li, Honglin,Zhu, Lili,Zhou, Hongchang,Zhao, Zhenjiang
, (2018/06/08)
The inhibition of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) potentially represents a new treatment option for malaria, as P. falciparum relies entirely on a de novo pyrimidine biosynthetic pathway for survival. Herein, we report a series of pyrimidone derivatives as novel inhibitors of PfDHODH. The most potent compound, 26, showed high inhibition activity against PfDHODH (IC50 = 23 nM), with >400-fold species selectivity over human dihydroorotate dehydrogenase (hDHODH). The brand-new inhibitor scaffold targeting PfDHODH reported in this work may lead to the discovery of new antimalarial agents.
Studies of heterocyclic compounds. VIII. Synthesis, anti-inflammatory and antiallergic activities of N-alkyl-2,3,4,9-tetrahydrofuro[2,3-b]quinoline-3,4-diones and related compounds
Kuo,Huang,Huang,Cheng,Ling,Wu,Ishii,Nakamura
, p. 955 - 963 (2007/10/02)
-
Synthesis of furoquinolines
Yazima,Munakata
, p. 235 - 243 (2007/10/02)
-
