584-14-5Relevant articles and documents
Synthesis, characterization, and structural investigations of 1-amino-3-substituted-1,2,3-triazolium salts, and a new route to 1-substituted-1,2,3-triazoles
Kaplan, Greg,Drake, Greg,Tollison, Kerri,Hall, Leslie,Hawkins, Tommy
, p. 19 - 27 (2005)
Quarternary salts based upon 3-alkyl substituted 1-amino-1,2,3-triazolium cations (alkyl = methyl, ethyl, n-propyl, 2-propenyl, and n-butyl) have been synthesized and characterized by vibrational spectra, multinuclear NMR, elemental analysis, and DSC studies. Subsequent diazotization of these salts results in the exclusive formation of 1-alkyl-1,2,3-triazoles. Single crystal X-ray studies were carried out for 1-amino-3-methyl-1,2,3-triazolium iodide, 1-amino-3-ethyl-1,2,3-triazolium bromide, 1-amino-3-ra-propyl-1,2,3-triazolium bromide, and 1-amino-3-n-butyl-1,2,3-triazolium bromide as well as the starting heterocycle, 1-amino-1,2,3-triazole, and all of the structures are discussed.
1-AminoTriazole Transition-Metal Complexes as Laser-Ignitable and Lead-Free Primary Explosives
Szimhardt, Norbert,Wurzenberger, Maximilian H. H.,Zeisel, Lukas,Gruhne, Michael S.,Lommel, Marcus,Klap?tke, Thomas M.,Stierstorfer, J?rg
, p. 1963 - 1974 (2019)
This unique complex study describes two isomeric aminotriazoles as auspicious nitrogen-rich ligands for energetic coordination compounds (ECCs) to replace the commonly used highly poisonous and environmentally harmful lead-based primary explosives. The triazoles were obtained by easily scalable and convenient synthetic routes starting solely from commercially available starting materials. 1-Amino-1,2,3-triazole (1, 1-ATRI) and, for the first time, 1-amino-1,2,4-triazole (2, 1A-1,2,4-TRI) were employed as ligands to form highly energetic transition-metal(II) complexes. The desired characteristics could be altered successively by using various nonpoisonous metal(II) centers (Cu2+, Mn2+, Fe2+, and Zn2+) and anions (Cl?, NO3?, ClO3?, ClO4?, picrate, styphnate, 2,4,6-trinitro-3-hydroxyphenolate, and 2,4,6-trinitro-3,5-dihydroxyphenolate). The 14 synthesized coordination compounds were characterized comprehensively by XRD, IR and UV/Vis spectroscopy, elemental analysis, and differential thermal and thermogravimetric analyses. Ball-drop impact, electrostatic discharge (ESD), and mechanical (impact and friction) sensitivities were determined according to BAM standard methods. In addition to laser ignition experiments, selected ECCs were evaluated in classical secondary explosive initiation tests (detonators filled with pentaerythritol tetranitrate (nitropenta)), which revealed their enormous potential and proved them to be very attractive for future applications in explosives.
Method for continuously synthesizing 1H-1,2,3-triazole by using microchannel reactor
-
Paragraph 0020; 0046; 0048; 0052; 0054; 0058; 0060, (2021/05/19)
The invention relates to a method for continuously synthesizing 1H-1,2,3-triazole through a microchannel reactor, and belongs to the technical field of medicine synthesis. The method comprises the following steps: reacting a hydrazine hydrate aqueous solution and a glyoxal aqueous solution in a micro-channel reactor to prepare a material 1, continuously reacting the material 1 with hydrogen peroxide in the micro-channel reactor to prepare a material 2, and continuously mixing the material 2 with concentrated hydrochloric acid in the micro-channel reactor to obtain a material 3; conducting reaction on the material 3 and a sodium nitrite aqueous solution in the micro-channel reactor, and conducting post-treatment to obtian 1H-1,2,3-triazole. No solvent needs to be added or replaced in the reaction process, manganese dioxide and potassium permanganate which can generate solid waste are prevented from being used, and toxic substances such as toluenesulfonyl chloride and dioxane which are harmful to the environment are not used either; and the 1H-1,2,3-triazole can be safely produced.
Tazobactam intermediate, preparation method thereof and method for preparing tazobactam by using intermediate (by machine translation)
-
Paragraph 0051; 0068-0070, (2020/11/23)
The intermediate V is prepared from glyoxal and hydrazine through dihydrazone of glyoxal, 1 - 2-triazole, and then reacted with (2S, 3S) 3 methyl -3 -methyl-3 -oxo -7 -thio -4 -methylpyridine-1 -thioxazabicyclo [3.2.0 -2 -] heptanoic acid to obtain an intermediate VII, and an intermediate VII is subjected to deprotection reaction to prepare the tazobarbazobactam intermediate V; the intermediate V is subjected to diazotization reaction to prepare the intermediate V. The preparation method of tazobactam is mild in reaction condition, simple in process, low in cost, high 90% in yield, high 99.0% in purity, environmentally friendly, good in economic benefit and suitable for industrial production. (by machine translation)