584-87-2

Basic information

• Product Name: 3-FORMYL-4-HYDROXYBENZOIC ACID
• Synonyms: 3-FORMYL-4-HYDROXYBENZOIC ACID;3-FORMYL-4-HYDROXYBENZOIC ACID HEMIHYDRATE;4-HYDROXYISOPHTHALALDEHYDIC ACID;4-HYDROXYISOPHTHALALDEHYDIC ACID 97%;4-hydroxy-3-methanoyl-benzoic acid;3-ForMyl-4-hydroxybenzoic acid 97%;3-formyl-4-hydroxybenzonic acid
• CAS NO: 584-87-2
• Molecular Formula: C₈H₆O₄
• Molecular Weight: 166.13
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aldehydes;C8;Carbonyl Compounds
• Mol File: 584-87-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: 246-250 °C(lit.)
• Boiling Point: 254.32°C (rough estimate)
• Flash Point: 177 °C
• Appearance: /
• Density: 1.3579 (rough estimate)
• Vapor Pressure: 2.32E-05mmHg at 25°C
• Refractive Index: 1.5090 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.22±0.10(Predicted)
• CAS DataBase Reference: 3-FORMYL-4-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FORMYL-4-HYDROXYBENZOIC ACID(584-87-2)
• EPA Substance Registry System: 3-FORMYL-4-HYDROXYBENZOIC ACID(584-87-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/38
• Safety Statements: 26-36/37
• WGK Germany: 2
• Hazardous Substances Data: 584-87-2(Hazardous Substances Data)

Usage

General Description

3-Formyl-4-Hydroxybenzoic Acid is an organic compound that belongs to the class of chemicals known as salicylic acids and derivatives. These are compounds containing either an ortho-hydroxylated benzene ring bearing a carboxyl group, or its structural equivalent. It appears in the form of a solid substance and is also known by the systematic name, 3-Formyl-4-hydroxybenzoic acid. The specific properties such as melting point, boiling point, solubility, toxicity, among others, may depend on the purity grade and other technical conditions of this chemical. Its potential applications can vary and may be pertinent to chemical research or various industrial uses, subject to processes involving chemical reactions pertinent to its inherent structural properties.

InChI:InChI=1/C8H6O4/c9-4-6-3-5(8(11)12)1-2-7(6)10/h1-4,10H,(H,11,12)

Upstream product

• 99-96-7 4-hydroxy-benzoic acid 
• 75-07-0 acetaldehyde 
• 24589-99-9 methyl 3-formyl-4-hydroxybenzoate 
• 76-05-1 trifluoroacetic acid 
• 60-29-7 diethyl ether 
• 67-66-3 chloroform 
• 50-00-0 formaldehyd 
• 76-03-9 trichloroacetic acid 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 122055-75-8 2,5-dioxopyrrolidin-1-yl 3-formyl-4-hydroxybenzoate 
• 136084-60-1 2-butoxy-5-carboxybenzaldehyde 
• 82885-62-9 4-hydroxy-3-hydroxymethylbenzoic acid 
• 404354-44-5 3-formyl-4-hydroxybenzoyl chloride 
• 746651-70-7 N,N'-bis(6,6'-dicarboxylatesalicylidene)ethylenediimine 
• 90334-66-0 4-hydroxy-3-(((4-iodophenyl)imino)methyl)benzoic acid 
• 90334-65-9 3-{[(E)-4-Bromo-phenylimino]-methyl}-4-hydroxy-benzoic acid 
• 90334-63-7 3-{[(E)-4-Fluoro-phenylimino]-methyl}-4-hydroxy-benzoic acid 
• 90334-62-6 4-Hydroxy-3-[(E)-phenyliminomethyl]-benzoic acid 
• 90334-67-1 4-hydroxy-3-(((4-nitrophenyl)imino)methyl)benzoic acid 
• 136084-62-3 2-hexoxy-5-carboxybenzaldehyde 
• 136084-59-8 2-propoxy-5-carboxybenzaldehyde 
• 90334-64-8 3-{[(E)-4-Chloro-phenylimino]-methyl}-4-hydroxy-benzoic acid 
• 33257-38-4 4-hydroxy-5-iodo-isophthalaldehyde acid 

Relevant articles and documents

Salen-Co(III) insertion in multivariate cationic metal-organic frameworks for the enhanced cycloaddition reaction of carbon dioxide

The salen-Co(iii) motif was inserted into imidazolium-functionalized multivariate cationic zirconium metal-organic frameworks (MOFs). The salen-Co(iii), as a Lewis acid site, and the Br- of imidazolium, as a nucleophile, are synergistically catalytic for the enhanced cycloaddition reaction of carbon dioxide with epoxides.

Synthesis, characterization and in vitro evaluation of anticancer activity of a new water-soluble thiosemicarbazone ligand and its complexes

A new water-soluble thiosemicarbazone ligand, 4-hydroxyl-3-({[(methylamino)carbonothioyl] hydrazono}methyl)benzoic acid (H3LCOOH) and its complexes with Cu(II), Ni(II), Zn(II), Fe(III) and Mn(III) were synthesized and characterized.

Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNA

G-quadruplex (G4) DNA structures are involved in many important biological processes and can be linked to several human diseases. Drug-like low molecular weight compounds that target G4 structures are therefore interesting not only for their potential therapeutic properties but also for their potential use as chemical research tools. We report here on the development of methods to synthesize spiropyrans using a condensation-cyclisation reaction of quaternary salts of α-methyl quinoline or phenanthridine with salicylaldehydes. Evaluation of the synthesized phenanthridine spiropyrans' interactions with G4 DNA was performed with a Thioflavin T displacement assay, circular dichroism, Taq DNA polymerase stop assay, and NMR. This revealed that the substitution pattern on the phenanthridine spiropyrans was very important for their ability to bind and stabilize G4 structures. Some of the synthesized low molecular weight spirocyclic compounds efficiently stabilized G4 structures without inducing structural changes by binding the first G-tetrad in the G4 structure.

Redox supramolecular self-assemblies nonlinearly enhance fluorescence to identify cancer cells

Based on the nonlinear fluorescence enhancement, our H2O2 induced supramolecular self-assembly reveals a H2O2 threshold among multiple cancer and normal cells. Oxidative elimination restores an intramolecular hy