58484-44-9Relevant articles and documents
Bradshaw et al.
, p. 874 (1975)
Quick synthesis method of crown ethers
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Paragraph 0012-0014, (2018/04/28)
The invention discloses a quick synthesis method of crown ethers. Oxalyl chloride, propandioic acid, polyethylene glycol and toluene are subjected to heating reaction and then are subjected to subsequent processing to obtain a finished product. The method comprises the following steps: 1) enabling the oxalyl chloride and the propandioic acid to be subjected to reaction, and performing stirring atnormal temperature to prepare malonyl dichloride; 2) mixing the malonyl dichloride, the polyethylene glycol and the toluene at normal temperature in a container; 3) enabling the mixture to flow through a jacketed pipeline, heating a jacket with vapor, controlling the retention time of the reactant in the pipeline, and collecting the outflow reaction liquid; and 4) performing distillation, extraction, re-crystallization and the like on the outflow reaction liquid to obtain white acicular crystal. The synthesis method disclosed by the invention is simple in process and very short in reaction time, improves the yield, and can be used for obtaining different crown ethers by taking different polyethylene glycols as reactants.