58498-57-0

Basic information

• Product Name: 2(1H)-Pyridinone, 6-(1,1-dimethylethyl)-
• Synonyms: 2(1H)-Pyridinone, 6-(1,1-dimethylethyl)-;6-(tert-butyl)pyridin-2(1H)-one
• CAS NO: 58498-57-0
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• Mol File: 58498-57-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 153 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: 307.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.009±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.12±0.10(Predicted)
• CAS DataBase Reference: 2(1H)-Pyridinone, 6-(1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone, 6-(1,1-dimethylethyl)-(58498-57-0)
• EPA Substance Registry System: 2(1H)-Pyridinone, 6-(1,1-dimethylethyl)-(58498-57-0)

Safety Data

• Hazardous Substances Data: 58498-57-0(Hazardous Substances Data)

Usage

Chemical class

Pyridinones

Usage

Intermediate in the synthesis of pharmaceuticals, particularly in the production of antifungal medication terbinafine

Physical form

White to off-white crystalline powder

Molecular weight

169.24 g/mol

Importance

An important ingredient in the production of medications used to treat fungal infections in humans and animals.

Upstream product

• 25361-54-0 (2-amino-2-oxo-ethyl)triphenyl-phosphonium chloride 
• 55793-15-2 sodium 4,4-dimethyl-1,3-dioxo-pentane enolate 
• 97634-81-6 2-(cyanamino)-6-(tert-butyl)pyridine 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 97634-83-8 6-(1,1-dimethylethyl)-2-pyridinamine 
• 4138-19-6 6-tert-butyl-2-hydroxypyridine-3-carbonitrile 
• 86776-92-3 6-tert-butyl-2-oxo-3-pyridinecarboxylic acid 

Downstream Products

• 290333-90-3 2-tert-butyl-6-diphenylphosphinopyridine 
• 195044-14-5 2‐bromo‐6‐tert‐butylpyridine 
• 97691-23-1 2-(tert-butyl)-6-chloropyridine 

Relevant articles and documents

The AZARYPHOS family of ligands for ambifunctional catalysis: Syntheses and use in ruthenium-catalyzed anti-markovnikov hydration of terminal alkynes

The family of AZARYPHOS (aza-aryl-phosphane) phosphane ligands, containing a phosphine unit and sterically shielded nitrogen lone pairs in the ligand periphery, is introduced as a tool for developing ambifunctional catalysis by the metal center and nitrogen lone pairs in the ligand sphere. General synthetic strategies have been developed to synthesize over 25 examples of structurally diverse (6-aryl-2pyridyl)phosphanes (ARPYPHOS), (6alkyl-2-pyridyl)phosphanes (ALPY-PHOS), 4,6-disubsituted l,3-diazin-2ylphosphanes or l,3,5-triazin-2- ylphosphanes, quinazolinylphosphanes, quinolinylphosphanes, and others. The scalable syntheses proceed in a few steps. The incorporation of AZARYPHOS ligands (L) into complexes [RuCp(L)2(MeCN)][PF6] (Cp = cyclopentadieny1)gives catalysts for the anti-Markovnikov hydration of terminal alkynes of the highest known activities. Electronic and steric ligand effects modulate the reaction kinetics over a range of two orders of magnitude. These results highlight the importance of using structurally diverse ligand families in the process of developing cooperative ambifunctional catalysis by a metal and its ligand.

Reaction of Ketone Enolates with 2,4-Dichloropyrimidine. A Novel Pyrimidine to Pyridine Interconversion

Treatment of 2,4-dichloropyrimidine (1) with a series of ketone potassium enolate in liquid NH3 results in a novel ring transformation leading to the formation of 6-(cyanamino)pyridines (8a-c).An SN(ANRORC) mechanism initiated by nucleophilic addition of the enolate to C6 of 1 is proposed.The pyrimidine-pyridine transformation involves displacement of the N1-C2-N3 portion of pyrimidine with a C-C-N moiety, where the enolate contributes the C-C fragment while NH3 is shown, using 15N-labeled NH3, to be the N donor.