58547-67-4

Basic information

• Product Name: N-(4-FLUOROBENZOYL)PIPERIDINE
• Synonyms: (4-fluorophenyl)(piperidino)methanone;(4-Fluorophenyl)(piperidin-1-yl)methanone;(4-Fluorophenyl)carbonylpiperidine;1-Fluoro-4-(piperidinocarbonyl)benzene;N-(4-FLUOROBENZOYL)PIPERIDINE;1-(4-FLUOROBENZOYL)PIPERIDINE;N-(4-Fluorobenzoyl)piperidine 97%;N-(4-Fluorobenzoyl)piperidine97%
• CAS NO: 58547-67-4
• Molecular Formula: C₁₂H₁₄FNO
• Molecular Weight: 207.24
• Product Categories: Pyrans, Piperidines & Piperazines;Pyrans, Piperidines &Piperazines
• Mol File: 58547-67-4.mol
• Article Data: 25

Chemical Properties

• Melting Point: 60 °C
• Boiling Point: 332.5 °C at 760 mmHg
• Flash Point: 154.9 °C
• Appearance: /
• Density: 1.159 g/cm³
• Vapor Pressure: 0.000146mmHg at 25°C
• Refractive Index: 1.542
• PKA: -1.21±0.20(Predicted)
• CAS DataBase Reference: N-(4-FLUOROBENZOYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-FLUOROBENZOYL)PIPERIDINE(58547-67-4)
• EPA Substance Registry System: N-(4-FLUOROBENZOYL)PIPERIDINE(58547-67-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 58547-67-4(Hazardous Substances Data)

Usage

General Description

N-(4-Fluorobenzoyl)piperidine is a chemical compound that consists of a piperidine ring with a 4-fluorobenzoyl group attached to it. It is an organic compound that is often used in the research and development of pharmaceuticals and in the creation of new molecules for various applications. The compound has potential uses in the field of medicinal chemistry, particularly in the synthesis of drugs that target specific receptors or enzymes in the body. It may also have other industrial applications, such as in the production of polymers or other materials. Overall, N-(4-fluorobenzoyl)piperidine is a versatile compound with potential utility in various scientific and industrial contexts.

InChI:InChI=1/C12H14FNO/c13-11-6-4-10(5-7-11)12(15)14-8-2-1-3-9-14/h4-7H,1-3,8-9H2

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 1765-93-1 4-fluoroboronic acid 
• 1013-92-9 di(piperidin-1-yl)methanethione 
• 110-89-4 piperidine 
• 201230-82-2 carbon monoxide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 139592-92-0 4-fluorobenzylpiperidine 
• 2156-71-0 N-chloropiperidine 
• 352-32-9 p-fluorotoluene 
• 371-40-4 4-fluoroaniline 
• 332-01-4 1-((4-fluorophenyl)diazenyl)piperidine 
• 403-43-0 4-fluorobenzoyl chloride 
• 579-39-5 1,2-bis(4-fluorophenyl)ethane-1,2-dione 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 139592-92-0 4-fluorobenzylpiperidine 

Relevant articles and documents

Synthesis and studies on gem-fluorinated 2-azabicyclo[n.1.0]alkanes

Three novel amines all possessing gem-difluorocyclopropane, secondary amino group and a fused aliphatic cycle were synthesized by difluorocyclopropanation of N-Boc protected enamides. The compounds were stable when amino group was blocked by protonation o

Palladium-Catalyzed Desulfurative Amide Formation from Thioureas and Arylboronic Acids

The development of the reactivity on carbene complexes would lead to the creation of novel synthetic strategies. We discovered herein the Pd-catalyzed desulfurative amide formation involved Suzuki-Miyaura coupling reaction, notably the Pd complex was generated in situ from thioureas, Ag salt and Pd catalyst. Silver salt was essential for the construction of this type of carbenes from available and stable thioureas and well participated in the catalytic cycle. We report a method for the synthesis of arylamides from arylboronic acids, which greatly enriched the application of thiourea chemistry and expanded the application of the Suzuki-Miyaura coupling.

Cross-Dehydrogenating Coupling of Aldehydes with Amines/R-OTBS Ethers by Visible-Light Photoredox Catalysis: Synthesis of Amides, Esters, and Ureas

A straightforward synthesis of amides, ureas, and esters is reported by visible-light cross-dehydrogenating coupling (CDC) of aldehydes (or amine carbaldehydes) and amines/R-OTBS ethers by photoredox catalysis. The reaction is found to be general and high yielding. A plausible mechanistic pathway has been proposed for these transformations and is supported by appropriate controlled experiments.