58577-88-1

Basic information

• Product Name: (S)-2-AMINO-3-BENZYLOXY-1-PROPANOL
• Synonyms: (S)-2-AMINO-3-BENZYLOXY-1-PROPANOL;H-D-SERINOL(BZL);(S)-(-)-2-AMino-3-benzyloxy-1-propanol, 98+%;(S)-2-AMino-3-benzyloxypropan-1-ol;(2S)-2-Amino-3-(benzyloxy)propan-1-ol;(S)-(-)-2-AMino-3-benzyloxy-1-propal
• CAS NO: 58577-88-1
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.23
• Mol File: 58577-88-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 340.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.53±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: (S)-2-AMINO-3-BENZYLOXY-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-AMINO-3-BENZYLOXY-1-PROPANOL(58577-88-1)
• EPA Substance Registry System: (S)-2-AMINO-3-BENZYLOXY-1-PROPANOL(58577-88-1)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 58577-88-1(Hazardous Substances Data)

Usage

Uses

(S)-(-)-2-Amino-3-benzyloxy-1-propanol is used as an organic chemical synthesis intermediate.

Upstream product

• 10433-52-0 O-benzyl-D-serine 
• 84907-81-3 (2R)-3-benzyloxy-2-aminopropanoic acid methyl ester 
• 287107-19-1 (R)-4-Benzyloxymethyl-2-phenyl-4,5-dihydro-oxazole 
• 67799-98-8 Methyl-N-acetyl-O-benzyl-D-serinat 
• 35886-79-4 N-acetyl-O-benzyl-D-serine 
• 1738-72-3 L-serine benzyl ester 

Downstream Products

• 1189331-41-6 (5R)-5-[(benzyloxy)methyl]-[1,3,4]-oxathiazinane-3,3-dioxide 
• 1346123-14-5 methyl (S)-4-(3-benzyloxymethyl-1,1-dioxo-1λ⁶-isothiazolidin-2-yl)-2-methoxybenzoate 
• 1346124-56-8 (S)-[4-(3-benzyloxymethyl-1,1-dioxo-1λ⁶-isothiazolidin-2-yl)-2-methoxyphenyl][4-(2,4-dimethylphenyl)piperazin-1-yl]methanone 
• 497831-48-8 C₄₄H₇₆N₂O₁₂ 
• 497832-33-4 C₆₂H₁₁₈N₂O₁₂Si₃ 
• 497831-38-6 C₄₃H₇₄N₂O₁₂ 
• 1262536-15-1 C₆₁H₁₁₆N₂O₁₂Si₃ 
• 1262536-11-7 C₆₁H₁₁₈N₂O₁₃Si₃ 

Relevant articles and documents

Synthesis and structure-activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides'

Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections; however, the increasing prevalence of macrolide-resistant pathogens is a public health concern. Therefore, the development of new macrolide scaffolds with activities against resistant pathogens is urgently needed. An efficient method for reconstructing the erythromycin A macrolactone skeleton has been established. Based on this methodology, novel 15-membered macrolides, known as '11a-azalides', with substituents at the C12, C13, or C4″ positions were synthesized and their antibacterial activities were evaluated. These derivatives showed promising antibacterial activities against erythromycin-resistant Streptococcus pneumoniae. Among them, the C4″ substituted derivatives had the most potent activity against erythromycin-resistant S. pneumoniae.

Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

New oxathiazinane dioxides derived from d- and l-serine have been tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. Compound (R)-24 (R′ = BrCH2C6H 4-C6H4CH2) showed a cytotoxicity with IC50 ≈ 10 μM.

IMMUNOMODULATORY COMPOUNDS AND METHODS OF USE THEREOF

The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is directed to methods of stimulating and reducing immune responses, treating autoimmune conditions, treating allergic reactions and asthma, and preventing ischemic damage and asthma by administering one or more immunomodulatory compounds.