58609-73-7Relevant articles and documents
Electrochemical Benzylic C-H Functionalization with Isocyanides
Grimaud, Laurence,Guillot, Régis,Tang, Shanyu,Vincent, Guillaume,Vitale, Maxime R.
supporting information, p. 2125 - 2130 (2022/04/07)
We report the challenging direct carbamoylation or cyanation of benzylic C(sp3)-H bonds with an isocyanide via an electrochemical process giving rise to structures that are encountered in several biologically relevant compounds and drugs. This transformation proceeds under mild conditions without the need for any external oxidant and avoids the necessity to start from a prefunctionalized benzylic substrate or the deployment of the cation pool method. The anodic oxidation of the benzylic position and the subsequent addition of the isocyanide lead to the formation of a C-C bond and to a nitrilium cation that hydrolyzes to yield α-Aryl acetamide derivatives, whereas the elimination of a t-butyl cation delivers α-Aryl acetonitrile derivatives.
Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives
Srinivas, Dasari,Satyanarayana, Gedu
supporting information, p. 7353 - 7358 (2021/10/01)
Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol).
Application of novel dimethyl carbonate methylation catalyst in preparation α- methyl phenylacetic acid
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Paragraph 0059-0061, (2020/03/17)
The invention relates to the field, of medicine synthesis, and concretely relates to a novel dimethyl carbonate methylation catalyst α - in preparation IV methylbenzene acetic acid. as starting material I for preparing a target product, methylbenzeneacetic acid, by a methylation, decarboxylation and hydrolysis reaction, under the action of a catalyst by using a catalyst as a representative low-cost catalyst, in the form of a quaternary amine salt, and a catalyst prepared by using the catalyst as a representative low-cost catalyst, such as potassium α - potassium bromide acetate, as a catalyst, and a catalyst used in the, hydrolysis reaction of the quaternary, amine salt. IV. 98%. The preparation method comprises the following steps: preparing a target product from the quaternary ammonium. salt solution.