586410-08-4 Usage
Description
CIS-3,4',5-TRIMETHOXY-3'-HYDROXYSTILBENE is a derivative of Resveratrol, a naturally occurring polyphenol found in various plants. It is characterized by its apoptotic activity at nanomolar concentrations and has a chemical structure that results in a yellow oil appearance. CIS-3,4',5-TRIMETHOXY-3'-HYDROXYSTILBENE has demonstrated significant potential in the field of cancer research and treatment due to its ability to induce apoptosis in cancer cells.
Uses
Used in Anticancer Applications:
CIS-3,4',5-TRIMETHOXY-3'-HYDROXYSTILBENE is used as an anticancer agent for its potent apoptotic activity at nanomolar concentrations. It has an IC50 value of 0.3, indicating its high effectiveness in inducing cell death in cancer cells. CIS-3,4',5-TRIMETHOXY-3'-HYDROXYSTILBENE has shown activity against resistant HL60R cells, which are known for their resistance to traditional chemotherapeutic agents. The activity of CIS-3,4',5-TRIMETHOXY-3'-HYDROXYSTILBENE is higher than that of several classic chemotherapeutic agents, making it a promising candidate for the development of novel cancer treatments.
Used in Pharmaceutical Industry:
CIS-3,4',5-TRIMETHOXY-3'-HYDROXYSTILBENE is used as a pharmaceutical candidate for its potential applications in cancer research and treatment. Its apoptotic activity and ability to overcome resistance in cancer cells make it a valuable compound for the development of new drugs and therapies. The pharmaceutical industry can leverage this compound's properties to create innovative treatments for various types of cancer, potentially improving patient outcomes and survival rates.
Used in Research and Development:
CIS-3,4',5-TRIMETHOXY-3'-HYDROXYSTILBENE is used as a research tool for studying the mechanisms of apoptosis and cancer cell resistance. Its high potency and activity against resistant cancer cells make it an ideal candidate for investigating the underlying processes involved in cancer cell death and the development of drug resistance. Researchers can use this compound to gain a deeper understanding of cancer biology and to identify potential targets for the development of new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 586410-08-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,8,6,4,1 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 586410-08:
(8*5)+(7*8)+(6*6)+(5*4)+(4*1)+(3*0)+(2*0)+(1*8)=164
164 % 10 = 4
So 586410-08-4 is a valid CAS Registry Number.
586410-08-4Relevant articles and documents
CuI/1,10-phen/PEG promoted decarboxylation of 2,3-diarylacrylic acids: Synthesis of stilbenes under neutral and microwave conditions with an in situ generated recyclable catalyst
Zou, Yong,Huang, Qi,Huang, Tong-Kun,Ni, Qing-Chun,Zhang, En-Sheng,Xu, Tian-Long,Yuan, Mu,Li, Jun
, p. 6967 - 6974 (2013/10/08)
A series of trans- or cis-stilbenes have been synthesized in good to excellent yields via a functional group-dependent decarboxylation process from the corresponding 2,3-diaryl acrylic acids in a neutral CuI/1,10-phen/PEG-400 system under microwave conditions. The in situ generation of the recyclable catalytic complex, the use of environmentally benign solvent PEG-400, the operational simplicity, the short reaction times, as well as the functional group-dependent chemo- and stereo-selectivity have made the decarboxylation process a highly efficient and applicable protocol.
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents
Simoni, Daniele,Invidiata, Francesco Paolo,Eleopra, Marco,Marchetti, Paolo,Rondanin, Riccardo,Baruchello, Riccardo,Grisolia, Giuseppina,Tripathi, Ashutosh,Kellogg, Glen E.,Durrant, David,Lee, Ray M.
experimental part, p. 512 - 522 (2009/08/07)
A series of novel stilbene derivatives has been synthesized and studied with the main goal to investigate SAR of the amino compound 1a, as well as to improve its water solubility, a potentially negative aspect of the molecule that could be a serious obsta
Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers
Gao, Mingzhang,Wang, Min,Miller, Kathy D.,Sledge, George W.,Hutchins, Gary D.,Zheng, Qi-Huang
, p. 5767 - 5772 (2007/10/03)
New carbon-11 and fluorine-18 labeled stilbene derivatives, cis-3,5-dimethoxy-4′-[11C]methoxystilbene (4′-[11C]8a), cis-3,4′,5-trimethoxy-3′-[11C]methoxystilbene (3′-[11C]8b), trans-3,5-dimethoxy-4′-[11C]methoxystilbene (4′-[11C]10a), trans-3,4′,5-trimethoxy-3′-[11C]methoxystilbene (3′-[11C]10b), cis-3,5-dimethoxy-4′-[18F]fluorostilbene (4′-[18F]12a), and trans-3,5-dimethoxy-4′-[18F]fluorostilbene (4′-[18F]13a), were designed and synthesized as potential PET probes for aryl hydrocarbon receptor (AhR) in cancers.
