58690-18-9

Basic information

• Product Name: 1H-Indole-3-acetic acid, 1-ethyl-
• Synonyms: (1-ethyl-indol-3-yl)-acetic acid;HMS1700N07;<1-Ethyl-indolyl-(3)>-essigsaeure;1-Ethyl-3-indolessigsaeure;2-(1-ethyl-1H-indol-3-yl)acetic acid;(1-Aethyl-indol-3-yl)-essigsaeure;N-Ethyl-indol-essigsaeure-(3);1H-Indole-3-acetic acid,1-ethyl;1-ethylindole-3-acetic acid
• CAS NO: 58690-18-9
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.241
• Mol File: 58690-18-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-acetic acid, 1-ethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-acetic acid, 1-ethyl-(58690-18-9)
• EPA Substance Registry System: 1H-Indole-3-acetic acid, 1-ethyl-(58690-18-9)

Safety Data

• Hazardous Substances Data: 58690-18-9(Hazardous Substances Data)

Usage

Type

Synthetic plant hormone derivative

Role

Regulates plant growth and development

Common uses

Growth regulator, plant hormone supplement in agriculture

Benefits

Promotes root and shoot growth, improves fruit setting, increases crop yields

Research applications

Exploring effects on physiological processes

Potential applications

Biotechnology and bioengineering for enhanced productivity and quality of crops

Upstream product

• 88636-52-6 1-(1-ethyl-1H-indol-3-yl)ethan-1-one 
• 87-51-4 indole-3-acetic acid 
• 74-96-4 ethyl bromide 
• 75-03-6 ethyl iodide 
• 703-80-0 3-acetylindole 
• 125981-56-8 ethyl 1-ethylindole-3-glyoxalate 
• 100717-88-2 ethyl 2-(1-ethyl-1H-indol-3-yl)acetate 
• 51079-10-8 ethyl 2-(1H-indol-3-yl)-2-oxoacetate 
• 19798-77-7 4-amino-3-chloropyridine 

Relevant articles and documents

Chemical profiling of HIV-1 capsid-targeting antiviral PF74

The capsid protein (CA) of HIV-1 plays essential roles in multiple steps of the viral replication cycle by assembling into functional capsid core, controlling the kinetics of uncoating and nuclear entry, and interacting with various host factors. Targetin

Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in malignant tumors and plays important roles in multiple aspects of cancer aggressiveness. Thus, targeting STAT3 promises to be an attractive strategy for the treatment of advanced metastatic tumors. Bisindolylmaleimide alkaloid (BMA) has been shown to have anti-cancer activities and was thought to suppress tumor cell growth by inhibiting protein kinase C. In this study, we show that a newly synthesized BMA analog, BMA097, is effective in suppressing tumor cell and xenograft growth and in inducing spontaneous apoptosis. We also provide evidence that BMA097 binds directly to the SH2 domain of STAT3 and inhibits STAT3 phosphorylation and activation, leading to reduced expression of STAT3 downstream target genes. Structure activity relationship analysis revealed that the hydroxymethyl group in the 2,5-dihydropyrrole-2,5-dione prohibits STAT3 inhibitory activity of BMA analogs. Altogether, we conclude that the synthetic BMA analogs may be developed as anti-cancer drugs by targeting and binding to the SH2 domain of STAT3 and inhibiting the STAT3 signaling pathway.

Application of N-alkylindole compound to preparation of anti-HIV (Human Immunodeficiency Virus) medicaments

The invention discloses an indole compound shown as a general formula (I), and application of a pharmaceutically-acceptable salt of the indole compound to preparation of anti-HIV medicaments or health care products, and discloses a preparation method of the compound and application of a medicinal composition containing the compound to preparation of anti-HIV medicaments or health care products. (The structural formula of the compound is shown in the description.).