587-18-8

Basic information

• Product Name: Ethyl-4-(trifluoroMethoxy) benzoate
• Synonyms: Ethyl-4-(trifluoroMethoxy) benzoate;4-Trifluoromethoxybenzoic acid ethyl ester
• CAS NO: 587-18-8
• Molecular Formula: C₁₀H₉F₃O₃
• Molecular Weight: 234.1718696
• Mol File: 587-18-8.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl-4-(trifluoroMethoxy) benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl-4-(trifluoroMethoxy) benzoate(587-18-8)
• EPA Substance Registry System: Ethyl-4-(trifluoroMethoxy) benzoate(587-18-8)

Safety Data

• Hazardous Substances Data: 587-18-8(Hazardous Substances Data)

Upstream product

• 407-14-7 1-bromo-4-(trifluoromethoxy)benzene 
• 1906-57-6 potassium monoethyl oxalate 
• 294210-67-6 ethyl 4-(tributylstannyl)benzoate 
• 96898-10-1 tris(dimethylamino)sulfonium trifluoromethoxide 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 64-17-5 ethanol 
• 330-12-1 4-trifluoromethoxybenzoic acid 
• 24210-45-5 α,α-difluorophenoxyacetic acid 
• 2070902-77-9 trifluoromethyl 4-fluorobenzene-1-sulfonate 
• 94-09-7 p-aminoethylbenzoate 
• 780-31-4 methyl 4-(trifluoromethoxy)benzoate 
• 175277-18-6 4-trifluoromethoxybenzoyl hydrazine 
• 17118-74-0 ethyl oxalylchloride 

Downstream Products

• 122454-46-0 3-oxo-3-(4-(trifluoromethoxy)phenyl)propanenitrile 
• 1040723-93-0 2-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]propanenitrile 
• 1736-74-9 4-trifluoromethoxybenzyl alcohol 
• 4315-07-5 4-(trifluoromethoxy)phenylacetic acid 
• 49561-96-8 (4-trifluoromethoxy-phenyl)-acetonitrile 
• 50824-05-0 4-trifluoromethoxybenzyl bromide 

Relevant articles and documents

ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND

The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4CRBN E3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4CRBN E3 ubiquitin ligase.

Visible-Light Photoredox-Catalyzed and Copper-Promoted Trifluoromethoxylation of Arenediazonium Tetrafluoroborates

We report the development of photoredox-catalyzed and copper-promoted trifluoromethoxylation of arenediazonium tetrafluoroborates, with trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxylation reagent. This new method takes advantage of visible-light photoredox catalysis to generate the aryl radical under mild conditions, combined with copper-promoted selective trifluoromethoxylation. The reaction is scalable, tolerates a wide range of functional groups, and proceeds regioselectively under mild reaction conditions. Furthermore, mechanistic studies suggested that a Cs[Cu(OCF3)2] intermediate might be generated during the reaction.

O-Trifluoromethylation of Phenols: Access to Aryl Trifluoromethyl Ethers by O-Carboxydifluoromethylation and Decarboxylative Fluorination

A new strategy for the synthesis of aryl trifluoromethyl ethers (ArOCF3) by combining O-carboxydifluoromethylation of phenols and subsequent decarboxylative fluorination is reported. This protocol allows easy construction of functionalized trifluoromethoxybenzenes and trifluoromethylthiolated arenes (ArSCF3) in moderate to good yields. Moreover, it utilizes accessible and inexpensive reagents sodium bromodifluoroacetate and SelectFluor II and, thus, is practical for O-trifluoromethylation of phenols. The potential application of this method is demonstrated with the preparation of a plant-growth regulator, Flurprimidol.