58725-39-6

Basic information

• Product Name: N-Dodecanoyl-L-proline
• Synonyms: N-DODECANOYL-PROLINE;1-(1-oxododecyl)-L-proline;N-DODECANOYL-L-PROLINE;1-Dodecanoylpyrrolidine-2-carboxylic acid;1-Dodecanoyl-L-proline;N-Lauroyl-L-proline;Einecs 261-407-9
• CAS NO: 58725-39-6
• Molecular Formula: C₁₇H₃₁NO₃
• Molecular Weight: 297.43
• EINECS: 261-407-9
• Mol File: 58725-39-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 465.3 °C at 760 mmHg
• Flash Point: 235.2 °C
• Appearance: /
• Density: 1.031 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.492
• PKA: 3.70±0.20(Predicted)
• CAS DataBase Reference: N-Dodecanoyl-L-proline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Dodecanoyl-L-proline(58725-39-6)
• EPA Substance Registry System: N-Dodecanoyl-L-proline(58725-39-6)

Safety Data

• Hazardous Substances Data: 58725-39-6(Hazardous Substances Data)

Usage

General Description

N-Dodecanoyl-L-proline is a chemical compound that belongs to the class of fatty acid derivatives. It specifically consists of a dodecanoyl (lauric acid) group attached to the amino acid L-proline. N-Dodecanoyl-L-proline is often used in the formulation of cosmetic and personal care products due to its emollient and moisturizing properties. It can also act as a surfactant, helping to stabilize and solubilize other ingredients in formulations. Additionally, N-Dodecanoyl-L-proline has been studied for its potential as a drug delivery vehicle and as an ingredient in pharmaceutical formulations. Overall, N-Dodecanoyl-L-proline is a versatile compound with various applications in the cosmetic, personal care, and pharmaceutical industries.

InChI:InChI=1/C17H31NO3/c1-2-3-4-5-6-7-8-9-10-13-16(19)18-14-11-12-15(18)17(20)21/h15H,2-14H2,1H3,(H,20,21)/t15-/m0/s1

Upstream product

• 143-07-7 lauric acid 
• 147-85-3 L-proline 
• 609-36-9 rac-Pro-OH 
• 14565-47-0 N-succinimidyl laurate 

Relevant articles and documents

INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN FOR WHICH THE PI IS FROM 5.8 TO 8.5 AND A CO-POLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS

A composition in the form of an injectable aqueous solution, whose pH consists from 6.0 to 8.0, including at least: a basal insulin whose isoelectric point includes from 5.8 to 8.5; a co-polyamino-acid bearing carboxylate charges and hydrophobic radicals Hy, the co-polyamino-acid being constituted of glutamic or aspartic units and said hydrophobic radicals Hy according to the following formula I:

INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN WHEREIN THE PI IS COMPRISED FORM 5.8 TO 8.5 AND A CO-POLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS

In one embodiment, the composition according to the invention is characterized in that the co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical -Hy is chosen among the co-polyamino acids according to formula XXXb hereinafter: wherein, D represents, independently, either a group —CH2— (aspartic acid) or a group —CH2—CH2— (glutamic acid),X represents a cationic entity chosen in the group comprising alkali cations,Rb and Rb′, identical or different, are either a hydrophobic radical -Hy, or a radical chosen in the group consisting of an H, a C2 to C10 linear acyl group, a C3 to C10 branched acyl group, a benzyl, a terminal “amino acid” unit and a pyroglutamate, at least one of Rb and R′b is a hydrophobic radical -Hy,Q and Hy are as defined above.n+m represents the degree of polymerization DP of the co-polyamino acid, namely the mean number of monomeric units per co-polyamino acid chain and 5≤n+m≤250.

COMPOSITIONS SOUS FORME D'UNE SOLUTION AQUEUSE INJECTABLE COMPRENANT DU GLUCAGON HUMAIN ET UN CO-POLYAMINOACIDE

Physically stable compositions in the form of an injectable aqueous solution, wherein the pH is from 6.0 to 8.0, includes at least: a) human glucagon andb) a co-polyamino acid bearing carboxylate charges and hydrophobic radicals Hy. In one embodiment, the compositions further comprise a gut hormone.