58790-94-6Relevant articles and documents
Lipase-catalysed acylation of prostanoids
Parve, Omar,Jaerving, Ivar,Martin, Ivar,Metsala, Andrus,Vallikivi, Imre,Aidnik, Madis,Pehk, Tonis,Samel, Nigulas
, p. 1853 - 1858 (1999)
Natural prostaglandins (PG) F(2α) and E1 as well as (+)-cloprostenol were regioselectively 11-acylated using Novozym 435 as a catalyst and vinyl acetate as an acyl donor. Unlike the above compounds the 15-OH group of PGE2 was also acylated with a significant velocity under the same conditions. The enantiospecificity of the lipase-catalysed 11-acetylation of cloprostenol was established by separate treatment of (+)- and (-)-cloprostenols.
