5900-55-0

Basic information

• Product Name: 2-ACETAMINO-4-CHLOROTOLUENE
• Synonyms: N-(5-CHLORO-2-METHYLPHENYL)ACETAMIDE;2-ACETAMINO-4-CHLOROTOLUENE;4-CHLORO-2-ACETAMINOTOLUENE;5-Chloro-o-acetotoluidide
• CAS NO: 5900-55-0
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.63
• EINECS: 227-592-5
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 5900-55-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 129-130 °C
• Boiling Point: 319.6 °C at 760 mmHg
• Flash Point: 147.1 °C
• Appearance: /
• Density: 1.218 g/cm³
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• PKA: 14.46±0.70(Predicted)
• CAS DataBase Reference: 2-ACETAMINO-4-CHLOROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETAMINO-4-CHLOROTOLUENE(5900-55-0)
• EPA Substance Registry System: 2-ACETAMINO-4-CHLOROTOLUENE(5900-55-0)

Safety Data

• Hazardous Substances Data: 5900-55-0(Hazardous Substances Data)

Usage

Uses

5-Chloro-o-acetotoluidide, is an intermediate for the synthesis of Metolazone (M338750), which is a diruetic and an antihypertensive.

InChI:InChI=1/C15H15N3O2/c19-14(17-10-12-4-2-1-3-5-12)15(20)18-11-13-6-8-16-9-7-13/h1-9H,10-11H2,(H,17,19)(H,18,20)

Upstream product

• 64-19-7 acetic acid 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 120-66-1 N-(2-methylphenyl)acetamide 
• 75-36-5 acetyl chloride 
• 89-59-8 4-chloro-2-nitrotoluene 
• 108-24-7 acetic anhydride 
• 108-42-9 3-chloro-aniline 
• 588-07-8 3-Chloroacetanilide 
• 112359-25-8 5-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 93863-88-8 (5-bromo-6-chloroindol-3-yl)-β-D-galactopyranoside 
• 1607828-49-8 5-bromo-4-chloro-N-[(allyloxycarbonyl)methyl]anthranilic acid allyl ester 
• 50419-88-0 2-amino-5-bromo-4-chlorobenzene carboxylic acid 
• 1607828-44-3 N-acetyl-5-bromo-4-chloroanthranilic acid 
• 1607828-43-2 N-(4-bromo-5-chloro-2-methylphenyl)-acetamide 
• 3086-91-7 4-chloro-5-sulfamoylanthranilic acid 
• 17560-54-2 2-acetylamino-4-chloro-5-sulfamoyl-benzoic acid 
• 412336-41-5 2-(2-ethoxycarbonyl-acetylamino)-4-chloro-benzoic acid methyl ester 
• 1677-49-2 2,4,7-trichloroquinoline 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 13852-52-3 acetic acid-(3-chloro-6-methyl-2-nitro-anilide) 
• 5307-03-9 2-chloro-5-methyl-1,4-phenylenediamine 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 50-84-0 2,4 dichlorobenzoic acid 

Relevant articles and documents

METHODS AND COMPOSITIONS FOR TARGETING TREGS USING CCR8 INHIBITORS

Provided herein are compounds of Formula (I) which can be used as CCR8 inhibitors, which can be used as treatment or prevention of cancer using CCR8 inhibitors targeted tumor specific T regulatory cells.

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

Synthesis of magnetic Fe3O4@SiO2@Cu–Ni–Fe–Cr LDH: an efficient and reusable mesoporous catalyst for reduction and one-pot reductive-acetylation of nitroarenes

Abstract: Magnetically recoverable Fe3O4@SiO2@Cu–Ni–Fe–Cr LDH was prepared under co-precipitation conditions. Characterization of the mesoporous catalyst was confirmed using Fourier-transformed infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, vibration sample magnetometer, Brunauer–Emmett–Teller, thermogravimetric, differential thermogravimetric analyses and transmission electron microscopy. Reduction of nitroarenes to the corresponding arylamines and one-pot reductive-acetylation of nitroarenes to acetanilides were carried out successfully by nanoparticles of the immobilized Cu–Ni–Fe–Cr layered double hydroxide on silica-coated Fe3O4 in water as a green solvent. All reactions were carried out within 6–22?min affording arylamines and N-arylacetamides in high-to-excellent yields. Reusability of the core–shell nanocatalyst was examined six times without significant loss of its catalytic activity.