590417-83-7

Basic information

• Product Name: Benzeneethanol, 2-fluoro-alpha-methyl- (9CI)
• Synonyms: 2-FLUORO-ALPHA-METHYL-BENZENEETHANOL
• CAS NO: 590417-83-7
• Molecular Formula: C₉H₁₁FO
• Molecular Weight: 154.18
• Product Categories: HALIDE
• Mol File: 590417-83-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 219.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.094±0.06 g/cm3(Predicted)
• PKA: 14.75±0.20(Predicted)
• CAS DataBase Reference: Benzeneethanol, 2-fluoro-alpha-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanol, 2-fluoro-alpha-methyl- (9CI)(590417-83-7)
• EPA Substance Registry System: Benzeneethanol, 2-fluoro-alpha-methyl- (9CI)(590417-83-7)

Safety Data

• Hazardous Substances Data: 590417-83-7(Hazardous Substances Data)

Upstream product

• 234115-65-2 2-(2-fluorophenyl)-3-methyloxirane 
• 348-54-9 2-Fluoroaniline 
• 56314-65-9 1-allyl-2-fluorobenzene 
• 2836-82-0 (o-fluorophenyl)acetone 
• 549503-58-4 2-(2-fluorophenyl)-1-methylethyl diisopropylcarbamate 

Downstream Products

• 549503-59-5 (+)-2-(2-fluorophenyl)-1-methylethyl mesylate 
• 1450816-94-0 1-fluoro-2-(2-methoxypropyl)benzene 
• 1450816-80-4 (E)-ethyl 3-(3-fluoro-2-(2-methoxypropyl)phenyl)acrylate 
• 1238894-48-8 1-(2-fluorophenyl)propan-2-yl acetate 

Relevant articles and documents

Markovnikov Wacker-Tsuji Oxidation of Allyl(hetero)arenes and Application in a One-Pot Photo-Metal-Biocatalytic Approach to Enantioenriched Amines and Alcohols

The Wacker-Tsuji aerobic oxidation of various allyl(hetero)arenes under photocatalytic conditions to form the corresponding methyl ketones is presented. By using a palladium complex [PdCl2(MeCN)2] and the photosensitizer [Acr-Mes]ClO4 in aqueous medium and at room temperature, and by simple irradiation with blue led light, the desired carbonyl compounds were synthesized with high conversions (>80%) and excellent selectivities (>90%). The key process was the transient formation of Pd nanoparticles that can activate oxygen, thus recycling the Pd(II) species necessary in the Wacker oxidative reaction. While light irradiation was strictly mandatory, the addition of the photocatalyst improved the reaction selectivity, due to the formation of the starting allyl(hetero)arene from some of the obtained by-products, thus entering back in the Wacker-Tsuji catalytic cycle. Once optimized, the oxidation reaction was combined in a one-pot two-step sequential protocol with an enzymatic transformation. Depending on the biocatalyst employed, i. e. an amine transaminase or an alcohol dehydrogenase, the corresponding (R)- and (S)-1-arylpropan-2-amines or 1-arylpropan-2-ols, respectively, could be synthesized in most cases with high yields (>70%) and in enantiopure form. Finally, an application of this photo-metal-biocatalytic strategy has been demonstrated in order to get access in a straightforward manner to selegiline, an anti-Parkinson drug. (Figure presented.).

Facile Protocol for Catalytic Frustrated Lewis Pair Hydrogenation and Reductive Deoxygenation of Ketones and Aldehydes

A series of ketones and aldehydes are reduced in toluene under H2 in the presence of 5 mol % B(C6F5)3 and either cyclodextrin or molecular sieves affording a facile metal-free protocol for reduction to alcohols. Similar treatment of aryl ketones resulted in metal-free deoxygenation yielding aromatic hydrocarbons.

Ether-directed ortho-C-H olefination with a palladium(II)/monoprotected amino acid catalyst

Weak coordination is powerful! A PdII-catalyzed olefination of ortho-C-H bonds of arenes directed by weakly coordinating ethers is developed by using monoprotected amino acid (MPAA) ligands. This finding provides a method for chemically modifying ethers, which are abundant in natural products and drug molecules. HFIP=hexafluoroisopropanol. Copyright