592542-61-5

Basic information

• Product Name: (E)-Methyl 2-(2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylaMino)acetate
• Synonyms: (E)-Methyl 2-(2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylaMino)acetate;(E)-2,4,6-TriMethoxystyryl 3-(carboMethoxyMethylaMino)-4-Methoxybenzyl sulfone
• CAS NO: 592542-61-5
• Molecular Formula: C₂₂H₂₇NO₈S
• Molecular Weight: 465.51668
• Mol File: 592542-61-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-Methyl 2-(2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylaMino)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-Methyl 2-(2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylaMino)acetate(592542-61-5)
• EPA Substance Registry System: (E)-Methyl 2-(2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylaMino)acetate(592542-61-5)

Safety Data

• Hazardous Substances Data: 592542-61-5(Hazardous Substances Data)

Usage

General Description

(E)-Methyl 2-(2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylaMino)acetate is a chemical compound that belongs to the group of organic compounds known as aminophenyl ethers. It is a synthetic derivative of 2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylamine, and its molecular structure consists of a styrylsulfonyl methyl ether substituted with a 2-methoxyphenyl group and an amino group at the 5 position. (E)-Methyl 2-(2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylaMino)acetate is used in the synthesis of various pharmaceuticals and organic materials due to its unique chemical properties and reactivity. Additionally, it has potential applications in the field of medicinal chemistry and drug discovery due to its interaction with biological targets and its ability to modulate biological processes.

Upstream product

• 136612-71-0 (2,4,6-Trimethoxyphenyl)acetylene 
• 61010-34-2 3-nitro-4-methoxybenzyl bromide 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 41870-24-0 (4-methoxy-3-nitrophenyl)methanol 
• 119-10-8 4-methoxy-3-nitrotoluene 
• 1330633-87-8 2-(2’,2’-dibromovinyl)-1,3,5-trimethoxybenzene 
• 1330633-86-7 (E)-2',4',6'-trimethoxystyryl-4-methoxy-3-nitrobenzyl sulfide 
• 908344-21-8 3-nitro-4-methoxybenzyl mercaptan 
• 908344-08-1 (E)-2',4',6'-trimethoxystyryl-4-methoxy-3-aminobenzyl sulfide 
• 592542-51-3 4-methoxy-3-nitrophenylmethanesulfonyl acetic acid 
• 22216-44-0 2-(4-methoxy-3-nitrobenzylthio)acetic acid 
• 592542-50-2 (E)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)aniline 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 592542-59-1 (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetic acid 

Relevant articles and documents

Hydrothiolation of benzyl mercaptan to arylacetylene: Application to the synthesis of (E) and (Z)-isomers of on 01910·Na (Rigosertib), a phase III clinical stage anti-cancer agent

A stereoselective and efficient method for free radical addition of benzyl thiol to aryl acetylene in the presence of Et3B-hexane has been developed for the synthesis of (Z) and (E)-styryl benzyl sulfides where base catalyzed hydrothiolations h

COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA

Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.

COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA

Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: (I) wherein R1 is selected from the group consisting of -NH2, -NH-CH2-CO2H, -NH-CH(CH3)-CO2H, and -NH-C(CH3)2-CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.