59255-94-6

Basic information

• Product Name: 2-Bromo-3-fluoronitrobenzene
• Synonyms: 2-BROMO-3-FLUORONITROBENZENE;2-Bromo-1-fluoro-3-nitrobenzene;2-broMo-3-fluorobroMobezene;Benzene, 2-bromo-1-fluoro-3-nitro-
• CAS NO: 59255-94-6
• Molecular Formula: C₆H₃BrFNO₂
• Molecular Weight: 220
• EINECS: 1533716-785-6
• Product Categories: blocks;Bromides;FluoroCompounds;NitroCompounds
• Mol File: 59255-94-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 42.0-44.0 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 222.326 °C at 760 mmHg
• Flash Point: 88.26 °C
• Appearance: /
• Density: 1.808 g/cm³
• Vapor Pressure: 0.152mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromo-3-fluoronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-fluoronitrobenzene(59255-94-6)
• EPA Substance Registry System: 2-Bromo-3-fluoronitrobenzene(59255-94-6)

Safety Data

• Hazard Codes: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 59255-94-6(Hazardous Substances Data)

Usage

General Description

2-Bromo-3-fluoronitrobenzene is a specialized, multifunctional aromatic compound with a molecular formula of C6H3BrFNO2, principally used in the field of organic synthesis. This colorless to pale yellow liquid belongs to the class of organic compounds known as nitrobenzenes, characterized by a benzene ring with a nitro group attached to it. It contains atoms of bromine and fluorine, and the presence of a nitro group in its molecular structure can facilitate certain chemical reactions. As a reagent, it's principally involved in the syntheses of various organic products, and it may serve as a block builder in the pharmaceutical industry. Despite its utility in controlled laboratory environments, direct exposure can be harmful, necessitating appropriate safety measures during handling and storage.

InChI:InChI=1/C6H3BrFNO2/c7-6-4(8)2-1-3-5(6)9(10)11/h1-3H

Upstream product

• 99-09-2 3-nitro-aniline 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 342-52-9 N-(2-fluoro-6-nitrophenyl)acetamide 
• 399-31-5 N-(2-fluorophenyl)acetamide 
• 17809-36-8 2-fluoro-6-nitroaniline 

Downstream Products

• 1033225-32-9 (2-fluoro-6-nitrophenyl)phenylamine 
• 1233955-40-2 C₁₀H₁₁FN₂O₃ 
• 1384984-24-0 3-fluoro-2-(tetrahydrofuran-2-yl)aniline 
• 1386857-51-7 3-fluoro-2-tetrahydrofuran-2-yl-aniline hydrochloride salt 
• 1384984-22-8 2-(2-fluoro-6-nitro-phenyl)-2,3-dihydrofuran 

Relevant articles and documents

Preparation method of 2 -bromo -3 -fluoronitrobenzene

The preparation method of 2 -bromo -3 -fluoronitrobenzene comprises the following steps: (1) reacting m-nitroaniline with bromosuccinimide to generate a compound III. (2) Compound III reacts with sodium nitrite and fluoroboric acid to generate compound IV

Synthesis method of 2-bromo-5-fluoronitrobenzene

The invention discloses a synthesis method of 2-bromo-5-fluoronitrobenzene and belongs to the field of organic chemistry. The synthesis method comprises the steps: adding m-nitrofluorobenzene and dibromohydantoin into an organic solvent, carrying out heating, dropwise adding a sulfuric acid aqueous solution, carrying out a further heat insulation reaction after finishing dropping, and then, carrying out cooling to room temperature; separating an organic layer, carrying out washing to be neutral, and then, carrying out reduced-pressure desolvation to obtain a target product. A reaction system of the method is simple, raw materials are available, the sulfuric acid aqueous solution can be indiscriminately used many times, the wastewater content is low, and a simple and green approach is provided for the synthesis of the compound.

A simple base-mediated halogenation of acidic sp2 C-H bonds under noncryogenic conditions

(Chemical Equation Presented) A new method has been developed for in situ halogenation of acidic sp2 carbon-hydrogen bonds in heterocycles and electron-deficient arenes. Either selective monohalogenation or one-step exhaustive polyhalogenation is possible for substrates possessing several C-H bonds that are flanked by electron-withdrawing groups. For the most acidic arenes, such as pentafluorobenzene, K3PO4 base can be employed instead of BuLi for metalation/halogenation sequences.