59365-60-5

Basic information

• Product Name: 1-CHLORO-2-(1,2-ETHANEDIOL)BENZENE
• Synonyms: 1-CHLORO-2-(1,2-ETHANEDIOL)BENZENE
• CAS NO: 59365-60-5
• Molecular Formula: C₈H₉ClO₂
• Molecular Weight: 172.60886
• Mol File: 59365-60-5.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 322°C at 760 mmHg
• Flash Point: 148.5°C
• Appearance: /
• Density: 1.328g/cm³
• Vapor Pressure: 0.000119mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1-CHLORO-2-(1,2-ETHANEDIOL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-2-(1,2-ETHANEDIOL)BENZENE(59365-60-5)
• EPA Substance Registry System: 1-CHLORO-2-(1,2-ETHANEDIOL)BENZENE(59365-60-5)

Safety Data

• Hazardous Substances Data: 59365-60-5(Hazardous Substances Data)

Usage

Chlorinated benzene derivative

A compound derived from benzene by replacing one hydrogen atom with a chlorine atom, resulting in a chlorinated aromatic structure.

Hydroxyl group attachment

A hydroxyl group (-OH) is attached to the benzene ring, contributing to the compound's polarity and reactivity.

Industrial applications

1-CHLORO-2-(1,2-ETHANEDIOL)BENZENE is used in various industries for different purposes.

Solvent

It can dissolve other substances, making it useful in chemical processes and reactions.

Chemical intermediate

It serves as a precursor in the synthesis of other chemical compounds.

Reagent in organic synthesis

It is used as a reactant in the preparation of organic compounds.

Manufacture of pharmaceuticals

It may be used in the production of certain medications.

Agricultural chemicals

It can be utilized in the production of pesticides, herbicides, and other agricultural products.

Hazards and safety precautions

1-CHLORO-2-(1,2-ETHANEDIOL)BENZENE can pose risks to human health and the environment if not handled and stored properly.

Proper handling

Follow safety guidelines and use appropriate personal protective equipment (PPE) when working with this compound.

Storage

Store in a secure, labeled container, away from direct sunlight, heat, and incompatible substances.

Disposal

Dispose of any waste materials according to local regulations and safety guidelines.

InChI:InChI=1/C8H9ClO2/c9-7-4-2-1-3-6(7)8(11)5-10/h1-4,8,10-11H,5H2

Upstream product

• 62717-50-4 o-chlorostyrene oxide 
• 2039-87-4 2-chlorostyrene 
• 141-78-6 ethyl acetate 
• 133662-20-1 1-(2-chlorophenyl)-2-hydroxyethanone 
• 10421-85-9 2-chloromandelic acid 
• 34966-49-9 methyl 2-chlorobenzoylformate 
• 887641-69-2 C₁₅H₁₁ClO₃ 
• 27993-71-1 1-(2-chlorophenyl)-2-hydroxyethanone 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 34867-87-3 spirocyclobutylmalonoyl peroxide 
• 194085-74-0 carbamic acid (2R)-2-(2-chloro-phenyl)-2-hydroxy-ethyl ester 

Downstream Products

• 89-98-5 2-chloro-benzaldehyde 
• 59362-73-1 2-(bromomethyl)-4-(2-chlorophenyl)-2-(4-chlorophenyl)-1,3-dioxolane 
• 32345-65-6 (R)-(2-chlorophenyl)-1,2-ethanediol 
• 1291105-05-9 (R)-1-(2-chlorophenyl)ethane-1,2-diol-1,2-diacetate 
• 1291104-98-7 (S)-1-(2-chlorophenyl)ethane-1,2-diol-1,2-diacetate 
• 118-91-2 ortho-chlorobenzoic acid 
• 194085-57-9 (D/L)-2-Carbamoyloxy-2-o-chlorophenylethyl carbamate 
• 59363-85-8 1-[4-(2-chloro-phenyl)-2-(2,4-dichloro-phenyl)-[1,3]dioxolan-2-ylmethyl]-1H-imidazole 
• 59401-13-7 1-[2-(4-bromo-phenyl)-4-(2-chloro-phenyl)-[1,3]dioxolan-2-ylmethyl]-1H-imidazole 
• 59363-25-6 1-[4-(2-chloro-phenyl)-2-(4-chloro-phenyl)-[1,3]dioxolan-2-ylmethyl]-1H-imidazole 
• 59363-71-2 1-[4-(2-chloro-phenyl)-2-p-tolyl-[1,3]dioxolan-2-ylmethyl]-1H-imidazole 
• 62717-50-4 (R)-(-)-2-(2-chlorophenyl)oxirane 

Relevant articles and documents

Catalytic Diastereo- and Enantioconvergent Synthesis of Vicinal Diamines from Diols through Borrowing Hydrogen

We present herein an unprecedented diastereoconvergent synthesis of vicinal diamines from diols through an economical, redox-neutral process. Under cooperative ruthenium and Lewis acid catalysis, readily available anilines and 1,2-diols (as a mixture of diastereomers) couple to forge two C?N bonds in an efficient and diastereoselective fashion. By identifying an effective chiral iridium/phosphoric acid co-catalyzed procedure, the first enantioconvergent double amination of racemic 1,2-diols has also been achieved, resulting in a practical access to highly valuable enantioenriched vicinal diamines.

One-step method for preparing racemic aryl vicinal diol in pure water

The invention provides a one-step method for preparing racemic aryl vicinal diol in pure water. The method is characterized by comprising the following steps: dissolving metachloroperbenzoic acid intodeionized water, adding styrene compounds, heating in a water bath at 30 DEG C, stirring at a rotation speed of 200-300 revolutions per minute for reacting for 2-3 hours, extracting the reaction solution with ethyl acetate, drying, and removing the ethyl acetate, thereby obtaining the racemic aryl vicinal diol. According to the one-step method for preparing racemic aryl vicinal diol in pure waterdisclosed by the invention, the metachloroperbenzoic acid serves as an oxidizing agent in the deionized water, dihydroxylation of the styrene compounds is realized within 2-3 hours at high chemoselectivity and high yield, and the racemic aryl vicinal diol is prepared. The method avoids use of any organic solvent or heavy metal catalyst, is short in reaction time, mild in reaction condition, greenand environmental-friendly, simple in operation and readily available in catalyst, has potential application prospects, and solves the problems that the target product is low in yield, the catalyst is difficult to obtain, and the organic solvent is needed.

Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles

We herein report a transition-metal-free cross-coupling between secondary alkyl halides/mesylates and aryl/alkenylboronic acid, providing expedited access to a series of nonchiral/chiral coupling products in moderate to good yields. Stereospecific SN2-type coupling is developed for the first time with alkenylboronic acids as pure nucleophiles, offering an attractive alternative to the stereospecific transition-metal-catalyzed C(sp2)-C(sp3) cross-coupling.