59394-28-4

Basic information

• Product Name: 8-CHLORO-QUINOLINE-2-CARBALDEHYDE
• Synonyms: 8-CHLORO-QUINOLINE-2-CARBALDEHYDE;CHEMBRDG-BB 4003793;ASINEX-REAG BAS 10144674;TIMTEC-BB SBB010860;8-chloroquinoline-2-carbaldehyde(SALTDATA: FREE)
• CAS NO: 59394-28-4
• Molecular Formula: C₁₀H₆ClNO
• Molecular Weight: 191.61
• Mol File: 59394-28-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 129-131 °C
• Boiling Point: 349.3 °C at 760 mmHg
• Flash Point: 165 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 4.76E-05mmHg at 25°C
• Refractive Index: 1.692
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.99±0.50(Predicted)
• CAS DataBase Reference: 8-CHLORO-QUINOLINE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-CHLORO-QUINOLINE-2-CARBALDEHYDE(59394-28-4)
• EPA Substance Registry System: 8-CHLORO-QUINOLINE-2-CARBALDEHYDE(59394-28-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 59394-28-4(Hazardous Substances Data)

Usage

General Description

8-CHLORO-QUINOLINE-2-CARBALDEHYDE is a chemical compound with the molecular formula C11H7ClNO. It is a derivative of quinoline and contains a chloro group and a aldehyde functional group. 8-CHLORO-QUINOLINE-2-CARBALDEHYDE is commonly used in the synthesis of various pharmaceuticals and agrochemicals. It has been studied for its potential biological activities, including antimicrobial, antifungal, and antiparasitic properties. Additionally, 8-CHLORO-QUINOLINE-2-CARBALDEHYDE is also used as a building block in organic synthesis and drug discovery research. However, it is important to handle this compound with care as it may pose health and environmental hazards.

InChI:InChI=1/C10H6ClNO/c11-9-3-1-2-7-4-5-8(6-13)12-10(7)9/h1-6H

Upstream product

• 3033-82-7 8-chloroquinaldine 
• 1165569-14-1 3,9-dichloro-[1,2,3]triazolo[1,5-a]quinoline 

Relevant articles and documents

The deprotonative metalation of [1,2,3]triazolo[1,5-a]quinoline. Synthesis of 8-haloquinolin-2-carboxaldehydes

New highly functionalized triazoloquinolines were synthesized by applying polar organometallic methods. Double metalation and functionalization provided 3,9-dihalogenated triazoloquinolines. Ring opening of the triazole with loss of nitrogen has been perf

Copper-Catalyzed Aerobic Oxidation of Azinylmethanes for Access to Trifluoromethylazinylols

A copper-catalyzed oxygenation of methylazaarenes was found to occur in the absence of both ligand and additive, and has been successfully employed for the synthesis of trifluoromethylazinylketols. This synthetic strategy incorporates aerobic oxidation and a trifluoromethylation in one-pot and provides a novel method for the trifluoromethylation of aliphatic C-H bond.

Iron-catalyzed C-H bond functionalization for the exclusive synthesis of pyrido[1,2-a]indoles or triarylmethanols

The efficient and selective iron-catalyzed C-H activation of 2-benzhydrylpyridine derivatives was employed for the preparation of pyrido[1,2-a]indoles through an intramolecular C-H amination reaction. In the presence of molecular oxygen as the sole oxidant, the same 2-benzhydrylpyridines were also used for the synthesis of the corresponding tertiary alcohols. In these approaches, the iron catalyst was used to selectively activate the C(sp2)-H bond of 2-benzhydrylpyridine, in the case of the intramolecular ring-closing C-H amination reaction in which the pyridine nitrogen atom was a directing group as well as a nucleophile, and the C(sp3)-H bond of the same compound, in the case of the oxidation reaction to give the corresponding triaryl carbinol.