595-46-0Relevant articles and documents
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Plattner et al.
, (1953)
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Method for continuous-flow preparation of 2,2-dimethylmalonic acid
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Paragraph 0013, (2020/11/25)
The invention provides a method for continuous-flow preparation of 2,2-dimethylmalonic acid. According to the method, a micro-channel reactor is utilized, a 2,2-dimethyl propylene glycol solution is used as a material 1, nitric acid is used as a material 2, and the materials are introduced into the micro-channel reactor for continuous-flow synthesis of 2,2-dimethylmalonic acid, wherein the reaction temperature is 30-100 DEG C, and the reaction time is 20-100 s. Compared with a conventional tank reactor in the prior art, the method provided by the invention has the advantages that the reactiontime is greatly shortened, mass transfer and heat transfer are uniform, the amplification effect is avoided, and the yield is improved to a certain extent compared with a tank reaction; more importantly, a liquid holding volume of the method is small, so the potential risk of nitric acid oxidation is greatly reduced; and the safety and operability of the method are improved.
Preparation and Characterisation of a Bis-μ-Hydroxo-NiIII 2 Complex
Spedalotto, Giuseppe,Gericke, Robert,Lovisari, Marta,Farquhar, Erik R.,Twamley, Brendan,McDonald, Aidan R.
supporting information, p. 11983 - 11990 (2019/08/26)
Hydroxide-bridged high-valent oxidants have been implicated as the active oxidants in methane monooxygenases and other oxidases that employ bimetallic clusters in their active site. To understand the properties of such species, bis-μ-hydroxo-NiII 2 complex (1) supported by a new dicarboxamidate ligand (N,N′-bis(2,6-dimethyl-phenyl)-2,2-dimethylmalonamide) was prepared. Complex 1 contained a diamond core made up of two NiII ions and two bridging hydroxide ligands. Titration of the 1 e? oxidant (NH4)2[CeIV(NO3)6] with 1 at ?45 °C showed the formation of the high-valent species 2 and 3, containing NiIINiIII and NiIII 2 diamond cores, respectively, maintaining the bis-μ-hydroxide core. Both complexes were characterised using electron paramagnetic resonance, X-ray absorption, and electronic absorption spectroscopies. Density functional theory computations supported the spectroscopic assignments. Oxidation reactivity studies showed that bis-μ-hydroxide-NiIII 2 3 was capable of oxidizing substrates at ?45 °C at rates greater than that of the most reactive bis-μ-oxo-NiIII complexes reported to date.
Microwave assisted hydrolysis of Meldrum's acid derivatives and decarboxylation of derived malonic acids
Helavi,Solabannavar,Desai,Mane
, p. 174 - 175 (2007/10/03)
Microwave induced hydrolysis of alkyl Medrum's acids and decarboxylation of derived malonic acids using poly-4-vinylpyridine as a catalyst gives high yields of carboxylic acids in a short time.
