59514-89-5

Basic information

• Product Name: 2,4-DICHLORO-1,8-NAPHTHYRIDINE
• Synonyms: 2,4-DICHLORO-1,8-NAPHTHYRIDINE;3-(2-Hydroxyethyl)-2-Methyl-3,4-dihydro-4-quinazolinone
• CAS NO: 59514-89-5
• Molecular Formula: C₈H₄Cl₂N₂
• Molecular Weight: 199.04
• Mol File: 59514-89-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 123.0 to 127.0 °C
• Boiling Point: 299℃
• Flash Point: 163℃
• Appearance: /
• Density: 1.486
• Vapor Pressure: 0.00216mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.15±0.30(Predicted)
• CAS DataBase Reference: 2,4-DICHLORO-1,8-NAPHTHYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-1,8-NAPHTHYRIDINE(59514-89-5)
• EPA Substance Registry System: 2,4-DICHLORO-1,8-NAPHTHYRIDINE(59514-89-5)

Safety Data

• Hazardous Substances Data: 59514-89-5(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-1,8-naphthyridine is a chemical compound that belongs to the class of naphthyridine derivatives. It is a white to off-white crystalline powder that is sparingly soluble in water. 2,4-Dichloro-1,8-naphthyridine is used in the synthesis of pharmaceuticals and agrochemicals due to its unique chemical structure and reactivity. It is also known for its antimicrobial and antifungal properties. 2,4-Dichloro-1,8-naphthyridine is considered to be a valuable building block in the production of various organic compounds and is commonly used in research and development processes.

InChI:InChI=1/C8H4Cl2N2/c9-6-4-7(10)12-8-5(6)2-1-3-11-8/h1-4H

Upstream product

• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 59514-86-2 [1,8]naphthyridine-2,4-diol 
• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 
• 504-29-0 2-aminopyridine 
• 1663-67-8 malonoyl dichloride 
• 219775-95-8 1-benzyl-4-hydroxy-1,8-naphthyridin-2(1H)-one 

Downstream Products

• 1756-68-9 decahydro-[1,8]naphthyridine 
• 59514-93-1 4-chloro-1,8-naphthyridin-2-one 
• 1353968-26-9 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-hydroxy-ethyl)-2H-[2,7]naphthyridin-1-one 
• 1353968-39-4 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one 
• 1353968-43-0 2-(5-chloro-2-fluoro-phenyl)-4-[1-(2-morpholin-4-yl-ethoxy)-[2,7]naphthyridin-4-yl]-[1,8]naphthyridine 
• 1353968-55-4 2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine 
• 1353968-79-2 N'-{5-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-isoquinolin-8-yl}-N,N-diethyl-ethane-1,2-diamine 
• 1353969-27-3 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-1-(2-morpholin-4-yl-ethyl)-1H-[1,7]naphthyridin-2-one 
• 1353969-32-0 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethoxy)-[1,7]naphthyridine 
• 1353967-13-1 2-(2-fluoro-5-trifluoromethyl-phenyl)-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)-[1,8]naphthyridine 
• 1353969-93-3 2-(5-chloro-2-fluoro-phenyl)-4-(2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine 
• 1353969-96-6 2-(5-chloro-2-fluoro-phenyl)-4-(6-oxy-furo[2,3-c]pyridin-3-yl)-[1,8]naphthyridine 
• 1353967-23-3 2-(5-chloro-2-fluoro-phenyl)-4-[1-(2-methoxy-ethyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-[1,8]naphthyridine 
• 1353967-14-2 2-(5-chloro-2-fluoro-phenyl)-4-isoquinolin-5-yl-[1,8]naphthyridine 

Relevant articles and documents

INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF

Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.

2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER

The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particu

4-thio substituted quinoline and naphthyridine compounds

The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.