59557-05-0

Basic information

• Product Name: Butanoic acid, 3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester
• Synonyms: Butanoic acid, 3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester;MENTHYLACETOACETATE;3-Oxobutanoic acid (1R)-5β-methyl-2α-isopropylcyclohexyl ester;3-Oxobutyric acid (1β)-2α-isopropyl-5β-methylcyclohexyl ester;Acetoacetic acid (1R,3R,4S)-p-menthane-3-yl ester;Acetoacetic acid [(1R)-2α-isopropyl-5β-methylcyclohexane]-1β-yl ester;L-MENTHYL ACETOACETATE;laevo-menthyl acetoacetate
• CAS NO: 59557-05-0
• Molecular Formula: C₁₄H₂₄O₃
• Molecular Weight: 240.38
• Mol File: 59557-05-0.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 323.06°C (rough estimate)
• Flash Point: 129.9°C
• Appearance: /
• Density: 1.0730 (rough estimate)
• Vapor Pressure: 0.000678mmHg at 25°C
• Refractive Index: 1.5557 (estimate)
• CAS DataBase Reference: Butanoic acid, 3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(59557-05-0)
• EPA Substance Registry System: Butanoic acid, 3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(59557-05-0)

Safety Data

• Hazardous Substances Data: 59557-05-0(Hazardous Substances Data)

Usage

Chemical Properties

Clear, colorless or pale yellow liquid; minty aroma.

InChI:InChI=1/C14H24O3/c1-9(2)12-6-5-10(3)7-13(12)17-14(16)8-11(4)15/h9-10,12-13H,5-8H2,1-4H3/t10-,12+,13-/m0/s1

Upstream product

• 591-60-6 butyl acetoacetate 
• 2216-51-5 (-)-menthol 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 1694-31-1 tert-butyl acetoacetate 
• 2033-24-1 cycl-isopropylidene malonate 
• 75-36-5 acetyl chloride 
• 42490-66-4 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 105-45-3 acetoacetic acid methyl ester 
• 674-82-8 4-methyleneoxetan-2-one 
• 141-97-9 ethyl acetoacetate 
• 490-99-3 DL-neomenthol 
• 15356-70-4 menthol 
• 3623-52-7 isomenthol 

Downstream Products

• 116395-59-6 3-amino-crotonic acid menthyl ester 
• 158818-65-6 (1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 200569-84-2 (E)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylsulfanyl)-3-hydroxy-but-2-enoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 1203506-48-2 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl-6-chloro-2-methyl-4-phenyl-3-quinolinecarboxylate 
• 259250-89-0 (-)-Menthyl 4-(1-hydroxycyclohexyl)-3-oxobutanoate 
• 34294-87-6 2-Diazo-propionic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 256510-27-7 (1R,2S,5R)-(-)-mentyl-2-chloroacetoacetate 
• 121004-10-2 (S)-2-Acetyl-3-methyl-nonanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 74965-59-6 3-Oxo-hept-6-enoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 143317-15-1 4(R,S)-1,2,3,4-tetrahydro-1,6-dimethyl-4-(2-naphthyl)-2-oxo-5-pyrimidinecarboxylic acid 1-<<1S<1a,2a,5b>>-5-methyl-2-(1-methylethyl)cyclohexyl> ester 
• 159253-86-8 (Z)-(-)-(1R,2S,5R)-menthyl 3-oxo-2-phenylmethylene butanoate 
• 127236-74-2 (1R,2S,5R)-(-)-menthyl diazoacetoacetate 
• 74965-53-0 3-Oxo-oct-7-enoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 85720-00-9 l-menthyl 7-methyl-3-oxo-6-octenoate 

Relevant articles and documents

Preparation of β-Keto Esters by 4-DMAP-Catalyzed Ester Exchange

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Addition of Diazo Compounds ipso -C-H Bond to Carbon Disulfide: Synthesis of 1,2,3-Thiadiazoles under Mild Conditions

We describe here an operationally simple and straightforward synthesis method for a series of diverse 4,5-disubstituted 1,2,3-thiadiazoles via the nucleophilic addition of α-diazo carbonyl compounds to carbon disulfide. This method features using abundant and inexpensive carbon disulfide under mild reaction conditions.

Direct Carboxylation of the Diazo Group ipso-C(sp2)-H bond with Carbon Dioxide: Access to Unsymmetrical Diazomalonates and Derivatives

The direct carboxylation of the ipso-C(sp2)-H bond of a diazo compound with carbon dioxide under mild reaction conditions is described. This method is transition-metal-free, uses a weak base, and proceeds at ambient temperature under atmospheric pressure in carbon dioxide. The carboxylation exhibits high reactivity and is amenable to subsequent diversification. A series of unsymmetrical 1,3-diester/keto/amide diazo compounds are obtained with moderate to excellent yields (up to 99%) with good functional group compatibility.