59646-16-1

Basic information

• Product Name: 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole
• Synonyms: 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole;5H,6H,7H-pyrrolo[1,2-a]iMidazole
• CAS NO: 59646-16-1
• Molecular Formula: C₆H₈N₂
• Molecular Weight: 108.143
• Mol File: 59646-16-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 260.8 °C at 760 mmHg
• Flash Point: 111.5 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 0.0194mmHg at 25°C
• Refractive Index: 1.657
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole(59646-16-1)
• EPA Substance Registry System: 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole(59646-16-1)

Safety Data

• Hazardous Substances Data: 59646-16-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 5084, 1994 DOI: 10.1021/jo00096a066

InChI:InChI=1/C6H8N2/c1-2-6-7-3-5-8(6)4-1/h3,5H,1-2,4H2

Upstream product

• 137415-92-0 2-(4-chlorobutyl)imidazole 
• 191542-47-9 1-<3-(phenylselanyl)propyl>-2-(phenylsulfanyl)-1H-imidazole 

Downstream Products

• 1290087-39-6 Br^(1-)*C₁₆H₂₀N₃O₂⁽¹⁺⁾ 
• 1876473-42-5 (6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)boronic acid 
• 126647-11-8 5,6-dihydro-7H-2-benzylmercaptopyrrolo<1,2-a>imidazole 

Relevant articles and documents

Radical cyclisation onto imidazoles and benzimidazoles

New synthetic methodology has been developed for the synthesis of [1,2- a]fused imidazoles and benzimidazoles using intramolecular homolytic aromatic substitution. In the intramolecular substitution, N-(ω-alkyl) radicals are generated using Bu3SnH from N-(ω-phenylselanyl)alkyl side chains. Phenylselanyl groups are used as radical leaving groups to avoid problems in the N-alkylation of imidazoles and benzimidazoles. Arylsulfones for imidazoles, and phenylsulfides for benzimidazoles, are used at the leaving groups in the homolytic substitutions.