597-25-1

Basic information

• Product Name: Dimethyl morpholinophosphoramidate.
• Synonyms: Dimethyl morpholinophosphoramidate.;PHOSPHONICACID,MORPHOLINO-,DIMETHYLESTER;Dimethyl morpholinophosphonate;Morpholinophosphonic acid dimethyl ester;4-dimethoxyphosphorylmorpholine;Dimethyl (morpholin-4-yl)phosphonate
• CAS NO: 597-25-1
• Molecular Formula: C₆H₁₄NO₄P
• Molecular Weight: 195.16
• Mol File: 597-25-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 42.3°C
• Flash Point: 103.1°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 0.0266mmHg at 25°C
• Refractive Index: 1.454
• CAS DataBase Reference: Dimethyl morpholinophosphoramidate.(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl morpholinophosphoramidate.(597-25-1)
• EPA Substance Registry System: Dimethyl morpholinophosphoramidate.(597-25-1)

Safety Data

• Hazardous Substances Data: 597-25-1(Hazardous Substances Data)

Usage

General Description

Clear colorless slightly viscous liquid.

Air & Water Reactions

Sensitive to prolonged exposure to air. Water soluble. Slowly hydrolyzes upon exposure to moisture.

Reactivity Profile

Water soluble. Hydrolysis occurs rapidly on exposure to acids.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Dimethyl morpholinophosphoramidate. emits very toxic fumes of nitrogen oxides and phosphorous oxides.

Fire Hazard

Dimethyl morpholinophosphoramidate. is probably combustible.

InChI:InChI=1/C6H14NO4P/c1-9-12(8,10-2)7-3-5-11-6-4-7/h3-6H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 7412-25-1 morpholinodiphenylphosphine oxide 
• 102-77-2 4-(benzothiazole-2-sulfenyl)-morpholine 
• 121-45-9 phosphorous acid trimethyl ester 
• 96-36-6 methyl phosphite 

Relevant articles and documents

ON THE REACTION OF BENZOTHIAZOL-2-YL SULPHENAMIDES WITH PHOSPHITES

A study of the synthesis of phosphoramidates from phosphites and benzothiazol-2-yl-sulphenamides, indicates that a quinquecovalent phosphorane is an intermediate.Since the initial step in this reaction does not involve attack of phosphorus on nitrogen, it is unlikely that these sulphenamides will act as electrophilic aminating agents towards non-phosphorus nucleophiles.An efficient new method for preparing benzothiazol-2-yl-sulphenamides is reported.

REACTION OF SULFENAMIDES WITH DI-ALKYL AND TRIALKYL PHOSPHITES. AN EFFICIENT SYNTHESIS OF PHOSPHORAMIDATES BY UNUSUAL SUBSTITUTION AT S-N BOND IN (2-BENZOTHIAZOLYL)SULFENAMIDES

Regioselective attack of the trivalent phosphorus atom of dialkyl and trialkyl phosphites on either nitrogen or sulfur atom of sulfenamides has been found.The reaction of phenylsulfenamides with dialkyl phosphites yielded phosphorothiolates, whereas the treatment of (2-benzothiazolyl)sulfenamides with dialkyl and trialkyl phosphites gave phosphoramidates in excellent yields.