59786-32-2

Basic information

• Product Name: 3-Methoxypyridine-4-carboxylic acid methyl ester
• Synonyms: 3-Methoxypyridine-4-carboxylic acid methyl ester;4-Pyridinecarboxylic acid, 3-Methoxy-, Methyl ester;3-Methoxy-isonicotinic acid methyl ester
• CAS NO: 59786-32-2
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.16196
• Mol File: 59786-32-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 259.5°C at 760 mmHg
• Flash Point: 110.7°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 0.0129mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Methoxypyridine-4-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxypyridine-4-carboxylic acid methyl ester(59786-32-2)
• EPA Substance Registry System: 3-Methoxypyridine-4-carboxylic acid methyl ester(59786-32-2)

Safety Data

• Hazardous Substances Data: 59786-32-2(Hazardous Substances Data)

Usage

General Description

3-Methoxypyridine-4-carboxylic acid methyl ester is a chemical compound with the molecular formula C8H9NO3. It is a methyl ester derivative of 3-methoxypyridine-4-carboxylic acid and is commonly used in the pharmaceutical and agrochemical industries. 3-Methoxypyridine-4-carboxylic acid methyl ester is known for its potential use in the synthesis of various pharmaceutical intermediates and active ingredients. It is also used as a building block in the development of new drugs and agrochemical products. Additionally, 3-Methoxypyridine-4-carboxylic acid methyl ester may have applications in other fields such as material science and organic chemistry. Overall, this chemical compound has important industrial applications and is a valuable tool in the development of various products and processes.

InChI:InChI=1/C8H9NO3/c1-11-7-5-9-4-3-6(7)8(10)12-2/h3-5H,1-2H3

Upstream product

• 82673-74-3 methyl 3-amino-5-methoxypyridine-4-carboxylate 
• 10128-71-9 3-hydroxyisonicotinic acid 
• 67-56-1 methanol 
• 654663-32-8 3-methoxypyridine-4-carboxylic acid 
• 82673-73-2 3-amino-5-methoxypyridine-4-carboxylic acid 
• 77903-35-6 3-Methoxy-5-(pivaloylamino)pyridine-4-carboxylic Acid 
• 124-41-4 sodium methylate 
• 103698-10-8 methyl 3-nitropyridine-4-carboxylate 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 186581-53-3 diazomethane 
• 10128-72-0 methyl 3-hydroxypyridine-4-carboxylate 

Downstream Products

• 102074-60-2 4-(hydroxymethyl)-3-methoxypyridine 
• 83431-06-5 3-methylisooxozolo<5,4-c>pyridine 
• 30152-05-7 1-(3-hydroxypyridin-4-yl)ethan-1-one 
• 83431-02-1 1-(3-methoxypyridin-4-yl)-ethanone 

Relevant articles and documents

Nucleophilic aromatic substitution of methyl 3-nitropyridine-4-carboxylate

The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by nitrogen, oxygen and sulphur nucleophiles by nucleophilic aromatic substitution to give the 3-azido, 3-methoxy, 3-phenoxy and 3-thiophenoxypyridine-4-carboxylate

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated "spin-center shift" (SCS) mechanism. Alcohols, however, remain underused as alkylating agents in synthetic chemistry due to their low reactivity in two-electron pathways. We report herein an enantioselective α-benzylation of aldehydes using alcohols as alkylating agents based on the mechanistic principle of spin-center shift. This strategy harnesses the dual activation modes of photoredox and organocatalysis, engaging the alcohol by SCS and capturing the resulting benzylic radical with a catalytically generated enamine. Mechanistic studies provide evidence for SCS as a key elementary step, identify the origins of competing reactions, and enable improvements in chemoselectivity by rational photocatalyst design.

Synthetic Application of Lithiation Reactions: A Convenient Synthesis of 3,4-Dihydro-5-hydroxycarbostyril, 1,2,3,4-Tetrahydro-5-hydroxy-2-oxo-1,7-naphthyridine, and Methyl 3-Methoxypyridine-4-carboxylate

3,4-Dihydro-5-hydroxycarbostyril (3), a key intermediate for a clinically used β-receptor blocking agent (1), and its 7-aza analog (4) were prepared by an acid-catalyzed cyclization of the N-pivaloylamino-esters (17 and 19), which were obtained by using o