598-72-1 Usage
Description
DL-2-Bromopropionic is a clear colorless to yellowish liquid that is soluble in water and miscible with alcohol, ether, chloroform, and benzene. It is an organic synthesis intermediate with various applications in different industries.
Uses
Used in Pharmaceutical and Agrochemical Industries:
DL-2-Bromopropionic is used as a pharmaceutical and agrochemical intermediate for its versatile reactivity and ability to serve as an alkylation agent for mercaptans and other sulfur-containing compounds.
Used in Emulsion Polymerization:
In the chemical industry, DL-2-Bromopropionic Acid is used as a reactant in emulsion polymerization, specifically in the preparation of reversible addition-fragmentation chain transfer (RAFT) agents.
Used in Herbicide Production:
DL-2-Bromopropionic acid is employed as an organic synthesis intermediate in the production of various herbicides, including quizalofop-ethyl, napropamide, and fenthiaprop.
Used in Fungicide Production:
It is also utilized in the synthesis of fungicides such as metalaxyl, benalaxyl, and procymidone.
Used in Pharmaceutical Intermediates:
DL-2-Bromopropionic acid is used in the synthesis of pharmaceutical intermediates, including body alanine, which is an important component in the development of various medications.
Preparation
2-Bromopropionic acid is obtained by bromination of propionic acid. Add propionic acid and phosphorus trichloride to the reaction kettle, keep the temperature at 80°C, slowly add bromine to the reaction solution dropwise, and heat up to 85°C after the addition of bromine, and raise the temperature to 100°C when the color of bromine disappears completely, it takes about 2~3h, and then the bromine and hydrobromic acid are recovered under reduced pressure, and then the finished product is obtained by distillation under reduced pressure.
Check Digit Verification of cas no
The CAS Registry Mumber 598-72-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 598-72:
(5*5)+(4*9)+(3*8)+(2*7)+(1*2)=101
101 % 10 = 1
So 598-72-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H5BrO2/c1-2(4)3(5)6/h2H,1H3,(H,5,6)/p-1/t2-/m0/s1
598-72-1Relevant articles and documents
1,3,2-Diazaphospholenes Catalyze the Conjugate Reduction of Substituted Acrylic Acids
Reed, John H.,Cramer, Nicolai
, p. 4262 - 4266 (2020/07/13)
The potent nucleophilicity and remarkably low basicity of 1,3,2-diazaphospholenes (DAPs) is exploited in a catalytic, metal-free 1,4-reduction of free α,β-unsaturated carboxylic acids. Notably, the reduction occurs without a prior deprotonation of the carboxylic acid moiety and hence does not consume an additional hydride equivalent. This highlights the excellent nucleophilic character and low basicity of DAP-hydrides. Functional groups such as Cbz group or alkyl halides which can be problematic with classical transition-metal catalysts are well tolerated in the DAP-catalyzed process. Moreover, the transformation is characterized by a low catalyst loading, mild reaction conditions at ambient temperature as well as fast reaction times and high yields. The proof-of-principle for a catalytic enantioselective version is described.
Catalytic Bromination of Alkyl sp3C-H Bonds with KBr/Air under Visible Light
Zhao, Mengdi,Lu, Wenjun
supporting information, p. 5264 - 5267 (2018/09/12)
Alkyl sp3C-H bonds of cycloalkanes and functional branch/linear alkanes have been successfully brominated with KBr using air or O2 as an oxidant at room temperature to 40 °C. The reactions are carried out in the presence of catalytic NaNO2 in 37% HCl (aq)/solvent under visible light, combining aerobic oxidations and photochemical radical processes. For various alkane substrates, CF3CH2OH, CHCl3, or CH2Cl2 is employed as an organic solvent, respectively, to enhance the efficiency of bromination.
CATALYSTS FOR MAKING ACRYLIC ACID FROM LACTIC ACID OR ITS DERIVATIVES IN LIQUID PHASE
-
Page/Page column 66, (2018/02/28)
Catalysts for the dehydration of lactic acid, lactic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof in liquid phase comprising an ionic liquid (IL) and an acid are provided.