59831-64-0

Basic information

• Product Name: milenperone
• Synonyms: milenperone;5-Chloro-1-[3-[4-(4-fluorobenzoyl)piperidino]propyl]-1,3-dihydro-2H-benzimidazol-2-one;R-34009;5-Chloro-1-[3-[4-(4-fluorobenzoyl)-1-piperidinyl]propyl]-1,3-dihydro-2H-benziMidazol-2-one
• CAS NO: 59831-64-0
• Molecular Formula: C₂₂H₂₃ClFN₃O₂
• Molecular Weight: 415.894
• EINECS: 261-947-5
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 59831-64-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.287g/cm³
• Refractive Index: 1.592
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: milenperone(CAS DataBase Reference)
• NIST Chemistry Reference: milenperone(59831-64-0)
• EPA Substance Registry System: milenperone(59831-64-0)

Safety Data

• Hazardous Substances Data: 59831-64-0(Hazardous Substances Data)

Usage

Description

Milenperone is a specific serotonin-S2 antagonist, characterized by its selective action on the serotonin system. It is a pharmaceutical compound that has been found to be particularly effective in managing behavioral disorders associated with epilepsy and alcoholism. Its mechanism of action involves targeting the serotonin-S2 receptors, which play a crucial role in modulating various behavioral and neurological functions.

Uses

Used in Pharmaceutical Industry:
Milenperone is used as a therapeutic agent for the control and management of behavioral disorders in patients with epilepsy and alcoholism. Its selective action on the serotonin-S2 receptors helps in addressing the underlying neurological imbalances that contribute to these disorders, thereby improving the patient's quality of life and overall well-being.
Used in Neurological Applications:
In the field of neurology, milenperone is utilized as a targeted treatment for specific neurological conditions that involve the serotonin system. Its ability to selectively bind to the serotonin-S2 receptors makes it a valuable tool in the development of novel therapies for a range of neurological disorders, including epilepsy and alcoholism-related behavioral issues.
Used in Research and Development:
Milenperone is also used in research and development for the study of the serotonin system and its role in various neurological and psychiatric conditions. Its selective antagonistic properties make it an important compound for investigating the mechanisms underlying these disorders and for the development of new drugs with improved efficacy and safety profiles.

InChI:InChI=1/C22H23ClFN3O2/c23-17-4-7-20-19(14-17)25-22(29)27(20)11-1-10-26-12-8-16(9-13-26)21(28)15-2-5-18(24)6-3-15/h2-7,14,16H,1,8-13H2,(H,25,29)

Upstream product

• 56346-57-7 (4-fluorophenyl)-piperidin-4-ylmethanone 
• 67-66-3 chloroform 
• 108-10-1 4-methyl-2-pentanone 
• 62780-79-4 5-chloro-1-(3-methanesulfonyloxy-propyl)-1,3-dihydro-benzoimidazol-2-one 

Relevant articles and documents

1-Benzazolylalkyl-4-substituted-piperidines

Compounds of the class of 1-(benzazolyalkyl)piperidine derivatives, useful as neuroleptic agents.