59855-11-7Relevant articles and documents
Therapeutic quinazoline derivatives
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, (2008/06/13)
A compound of formula (I) or a salt, ester, amide or prodrug thereof; where X is O, or S, S(O), S(O)2 or NR6 where R6 is hydrogen of C1-6alkyl; R5 is an optionally substituted 6-membered aromatic ring containing at least one nitrogen atom, and R1, R2, R3, R4 are independently selected from halogeno, cyano, nitro, C1-3alkylsulphanyl, —N(OH)R7— (wherein R7 is hydrogen, or C1-3alkyl), or R9X1— (wherein X1 represents a direct bond, —O—, —CH2—, —OC(O), —C(O)—, —S—, —SO—, —SO2—, —NR10C(O)—, —C(O)NR11—, —SO2NR12—, —NR13SO2— or NR14— (wherein R10, R11, R12, R13 and R14 each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl), and R9 is hydrogen, optionally substituted hydrocarbyl, optionally substituted heterocyclyl or optionally substituted alkoxy; provided that at least one of R2 or R3 is other than hydrogen. These compounds inhibit aurora 2 kinase and are useful in the preparation of medicaments for the treatment of proliferative disease such as cancer.
Heterobiarly derivatives and pharmaceutical compositions thereof
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, (2008/06/13)
Heterobiaryl derivatives of the formula wherein R1, X1 to X3 and Y1 to Y4 are as defined herein, the tautomers, stereoisomers and mixtures thereof, and the salts, particularly the physiologica
Pyrimidine derivatives
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, (2008/06/13)
Optically active pyrimidines of the formula STR1 wherein Z is --(CH2)n -- or --(CH2)n --O-- wherein n is an integer of 1 to 4 and each of the symbols X is a nitrogen atom and each of the symbols Y is --CH-- or e
