599175-38-9

Basic information

• Product Name: Uridine, 5-bromo-4-O-(2-nitrophenyl)-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3- disiloxanediyl]-
• CAS NO: 599175-38-9
• Molecular Formula: C27H40BrN3O9Si2
• Molecular Weight: 686.704
• Mol File: 599175-38-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Uridine, 5-bromo-4-O-(2-nitrophenyl)-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3- disiloxanediyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5-bromo-4-O-(2-nitrophenyl)-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3- disiloxanediyl]-(599175-38-9)
• EPA Substance Registry System: Uridine, 5-bromo-4-O-(2-nitrophenyl)-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3- disiloxanediyl]-(599175-38-9)

Safety Data

• Hazardous Substances Data: 599175-38-9(Hazardous Substances Data)

Upstream product

• 102789-25-3 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-5-bromouridine 
• 88-75-5 2-hydroxynitrobenzene 
• 957-75-5 5-bromouridine 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 

Downstream Products

• 599175-36-7 N-[2-(3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl}-2-oxo-2,9-dihydro-3H-10-oxa-1,3,9-triaza-anthracen-8-yloxy)-ethyl]-2,2,2-trifluoro-acetamide 
• 599175-33-4 (2-{2-[5-Bromo-2-oxo-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1,2-dihydro-pyrimidin-4-ylamino]-3-hydroxy-phenoxy}-ethyl)-carbamic acid benzyl ester 
• 599175-32-3 5-Bromo-4-(2,6-dihydroxy-phenylamino)-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidin-2-one 
• 599175-34-5 {2-[3-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-2-oxo-2,9-dihydro-3H-10-oxa-1,3,9-triaza-anthracen-8-yloxy]-ethyl}-carbamic acid benzyl ester 
• 599175-30-1 5-Bromo-4-(2-nitro-phenoxy)-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidin-2-one 

Relevant articles and documents

The synthesis of 2'-O-methyl G-clamp containing oligonucleotides and their inhibition of the HIV-1 Tat-TAR interaction.

We have synthesised a 2'-O-methyl riboside phosphoramidite derivative of the cytosine analogue 9-(2-aminoethoxy)-phenoxazine ('G-clamp') and successfully incorporated it into a series of small steric blocking 2'-O-methyl oligonucleotides targeting the stem-loop region of HIV-1 TAR RNA. The 'G-clamp' containing oligonucleotides show significant increases in binding to a model TAR RNA system when the 'G-clamp' is positioned opposite the loop region. The oligonucleotides also display dose-dependent inhibition of Tat-dependent transcription of an HIV DNA template in HeLa cell nuclear cell extract.