59985-21-6Relevant articles and documents
Preparation method of P,P-di(uridine 5'-)tetraphosphate
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Paragraph 0063-0064, (2020/01/25)
The invention relates to the technical field of medicine synthesis, in particular to a preparation method of a P,P-di(uridine 5'-)tetraphosphate. The preparation method of P,P-di(uridine 5'-)tetraphosphate as shown in a formula I comprises the step that a phosphoryl imidazole active compound as shown in a formula II or a formula III and a phosphoric acid active compound or a salt thereof undergo a reaction in an aqueous or hydrophilic solvent in the presence of gadolinium (III) ions or samarium (III) ions, so that the P,P-di(uridine 5'-)tetraphosphate (as shown in the description) is prepared.
An industrial preparation process of tetrasodium P,P-di(uridine-5')tetraphosphate
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Paragraph 0053; 0061; 0062; 0064; 0066, (2018/07/07)
An industrial preparation process of tetrasodium P,P-di(uridine-5')tetraphosphate is provided. The process includes preparing cyclic triphosphoric acid from a tributylamine salt of UTP by utilizing a carbodiimide type condensating agent; reacting the cyclic triphosphoric acid with a tributylamine salt of UMP to synthesize P,P-di(uridine-5')tetraphosphoric acid; directly salifying the reaction solution, without concentration, with a salt of an organic acid; performing crystallization; performing gradient elution with anion exchange resin after dissociation; subjecting the eluate, without the need of water concentration, to salt removing and water removing through membrane filtration; and then salifying to obtain the high-purity tetrasodium P,P-di(uridine-5')tetraphosphate.The tetrasodium P,P-di(uridine-5')tetraphosphate meeting officinal requirements can be prepared in a large scale by the process.
High-purity P1,P4-bis(uridine-5'-tetraphosphoric acid) salt preparation method
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, (2017/10/13)
The invention provides a P1,P4-bis(uridine-5'-tetraphosphoric acid) salt preparation method. The method includes: subjecting tributylamine salt of UTP to action of carbodiimide condensing agents; subjecting synthesis with excessive tributylamine salt of UMP to obtain P1,P4-bis(uridine-5'-tetraphosphoric acid); performing anion exchange resin gradient elution without water concentration, diluting, performing anion exchange resin elution again, and salifying and refining to obtain P1,P4-bis(uridine-5'-tetraphosphoric acid) salt. The method has advantages that the production cycle can be shortened remarkably, and products in medicinal purity can be obtained by preparation.