59997-51-2

Basic information

• Product Name: Pivaloylacetonitrile
• Synonyms: 4,4-dimethyl-3-oxo-pentanenitril;Pentanenitrile, 4,4-dimethyl-3-oxo-;CYANOPINACOLONE;4,4-DIMETHYL-3-OXO-N-VALERONITRILE;4,4-DIMETHYL-3-OXOPENTANENITRILE;4,4-dimethyl-3-oxovaleronitrile;1-CYANO-3,3-DIMETHYL-2-BUTANONE;PIVALOYLACETONITRILE
• CAS NO: 59997-51-2
• Molecular Formula: C₇H₁₁NO
• Molecular Weight: 125.17
• EINECS: 262-017-1
• Product Categories: BUILDING BLOCKS;Aliphatics;ketone;Agrochemicals
• Mol File: 59997-51-2.mol
• Article Data: 42

Chemical Properties

• Melting Point: 66-69 °C(lit.)
• Boiling Point: 125-126 °C22 mm Hg(lit.)
• Flash Point: 59.5 °C
• Appearance: White to cream/Crystals or Crystalline Powder
• Density: 1.0459 (rough estimate)
• Vapor Pressure: 0.0486mmHg at 25°C
• Refractive Index: 1.4693 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 10.25±0.10(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 1746674
• CAS DataBase Reference: Pivaloylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: Pivaloylacetonitrile(59997-51-2)
• EPA Substance Registry System: Pivaloylacetonitrile(59997-51-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 36/37/39-45
• RIDADR: UN 3439 6.1/PG 3
• WGK Germany: 3
• RTECS: SA2991000
• F: 8
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 59997-51-2(Hazardous Substances Data)

Usage

Chemical Properties

white to cream crystals or crystalline powder

Uses

Trimethylacetylacetonitrile is a useful intermediate. 4,4-Dimethyl-3-oxopentanenitrile has been used in the preparation of 4,4-dimethyl-3-oxo-2-benzylpentanenitrile, 4,4-dimethyl-3-oxo-2-(4-hydroxybenzyl)pentanenitrile, 4,4-dimethyl-3-oxo-2-(4-methoxybenzyl)pentanenitrile, 4,4-dimethyl-3-oxo-2-(4-fluorobenzyl)pentanenitrile, 4,4-dimethyl-3-oxo-2-(3,4-methylenedioxybenzyl)pentanenitrile, 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-phenylurea.

InChI:InChI=1/C7H11NO/c1-7(2,3)6(9)4-5-8/h4H2,1-3H3

Synthetic route

sodium cyanide (773837-37-9) + 1-chloro-3,3-dimethyl-butan-2-one (13547-70-1) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With sodium carbonate; sodium iodide In methanol at 60℃; for 3h;	95%

1-chloro-3,3-dimethyl-butan-2-one (13547-70-1) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
In methanol; sodium hydroxide	90%

3,3-dimethyl-butan-2-one (75-97-8) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium bicarbonate; chlorine In methanol; water; benzene	85%
Multi-step reaction with 2 steps 1: chloroform; SnCl4; bromine / -15 °C 2: alcohol / K-Salz View Scheme

4,4-dimethyl-3-ketovaleronitrile sodium salt → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With hydrogenchloride In water; dimethyl sulfoxide; toluene at 30℃; pH=2.0; Product distribution / selectivity;	78%
With hydrogenchloride In water; toluene at 20 - 30℃; pH=2.0; Product distribution / selectivity;	58%
With hydrogenchloride In water at 0℃; pH=7.0 - 7.7; Product distribution / selectivity;	57%

N-methoxy-N-methylpivalamide (64214-60-4) + acetonitrile (75-05-8) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
Stage #1: acetonitrile With methyllithium; lithium bromide In tetrahydrofuran; diethyl ether at -78℃; for 0.5h; Inert atmosphere; Stage #2: N-methoxy-N-methylpivalamide In tetrahydrofuran; diethyl ether at -78℃; for 1.5h; Inert atmosphere;	74%

Methyl pivalate (598-98-1) + acetonitrile (75-05-8) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With bromobenzene Ambient temperature; electrolysis;	60%
With bromobenzene; tetrabutylammonium tetrafluoroborate electroreduction;	60%
Stage #1: acetonitrile With sodium hydride In 1,4-dioxane; paraffin oil (nujol) for 0.75h; Stage #2: Methyl pivalate In 1,4-dioxane; paraffin oil (nujol) for 3h; Reflux;	51%

pivaloyl chloride (3282-30-2) + acetonitrile (75-05-8) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
Stage #1: acetonitrile With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; Stage #2: pivaloyl chloride In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;	41%

ethanol (64-17-5) + 2-chloromethyl-2-hydroxy-3,3-dimethyl-butyronitrile + sodium ethanolate (141-52-6) → 2,3-epoxy-2-tert-butyl-propionitrile + trimethylacetylacetonitrile (59997-51-2)

1-chloro-3,3-dimethyl-butan-2-one (13547-70-1) + sodium cyanide (143-33-9) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With ethanol

1-chloro-3,3-dimethyl-butan-2-one (13547-70-1) + potassium cyanide (151-50-8) → 2,3-epoxy-2-tert-butyl-propionitrile + trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With water

1-chloro-3,3-dimethyl-butan-2-one (13547-70-1) + potassium cyanide (151-50-8) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With ethanol

potassium cyanide (151-50-8) + 1-Bromopinacolon (5469-26-1) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With ethanol K-Salz;

3,5-di(tert-butyl )isoxazole (1132-15-6) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
In methanol Irradiation;

pivaloyl chloride (3282-30-2) + cyanoacetic acid (372-09-8) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With [2,2]bipyridinyl; n-butyllithium 1.) THF, hexane, -70 deg C --> 0 deg C, 2.) -70 deg C, 1 h; Yield given. Multistep reaction;
With hydrogenchloride; n-butyllithium In tetrahydrofuran; hexane

2,2-dimethyl-propanoic acid ethyl ester (3938-95-2) + acetonitrile (75-05-8) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With sodium hydride In tetrahydrofuran
With sodium hydride In 1,4-dioxane
With sodium hydride In tetrahydrofuran at 75℃; for 15h;
With sodium hydride In tetrahydrofuran at 80℃;
With sodium hydride In 1,4-dioxane; mineral oil at 20℃; for 16h;

1-chloro-3,3-dimethyl-butan-2-one (13547-70-1) + potassium cyanide (151-50-8) → trimethylacetylacetonitrile (59997-51-2) + α-tert-butyl-α-cyano-ethylene oxide

Conditions	Yield
With water

Methyl pivalate (598-98-1) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With hydrogenchloride In water; toluene; acetonitrile
With hydrogenchloride; hydrogen In water; toluene; acetonitrile
In tetrahydrofuran; water; acetonitrile
With ammonia; iron(III) chloride In diethyl ether; acetonitrile

acetonitrile (75-05-8) + pivalic acid ester → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With sodium hydride In toluene

pivaloyl chloride (3282-30-2) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 1.5 h / 0 - 20 °C 2.1: sodium hydride / 1,4-dioxane; paraffin oil / 0.75 h 2.2: 3 h / Reflux View Scheme
Multi-step reaction with 2 steps 1.1: 1.5 h / 0 - 20 °C 2.1: sodium hydride / 1,4-dioxane; paraffin oil (nujol) / 0.75 h 2.2: Reflux View Scheme
Multi-step reaction with 2 steps 1.1: 1.5 h / 0 - 20 °C 2.1: sodium hydride / 1,4-dioxane; paraffin oil (nujol) / 0.75 h 2.2: 3 h / Reflux View Scheme

sodium cyanide (773837-37-9) + 1-Bromopinacolon (5469-26-1) → trimethylacetylacetonitrile (59997-51-2)

Conditions	Yield
With hydrogenchloride In ethanol; water at 20℃;
Stage #1: sodium cyanide; 1-Bromopinacolon In ethanol; water for 16h; Stage #2: With hydrogenchloride In ethanol; water

trimethylacetylacetonitrile (59997-51-2) + (2,4-difluorophenyl)hydrazinium chloride (40594-29-4, 51523-79-6) → 3-tert-butyl-1-(2,4-difluorophenyl)-1H-pyrazol-5-amine (778611-49-7)

Conditions	Yield
Stage #1: trimethylacetylacetonitrile; (2,4-difluorophenyl)hydrazinium chloride With hydrogenchloride In ethanol for 12h; Heating / reflux; Stage #2: With sodium hydroxide In ethanol; water at 20℃; pH=12;	100%

trimethylacetylacetonitrile (59997-51-2) + 4-methoxyphenylhydrazine hydrochloride (19501-58-7) → 3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-amine (227623-26-9)

Conditions	Yield
for 18h; Reflux;	100%
With hydrogenchloride In ethanol for 48h; Reflux;	87%
In ethanol at 80℃;	80%

trimethylacetylacetonitrile (59997-51-2) + 1-(3-chloro-4-methylphenyl)hydrazine hydrochloride (54812-56-5) → 3-tert-butyl-1-(3-chloro-4-methylphenyl)-1H-pyrazol-5-amine (926242-93-5)

Conditions	Yield
With hydrogenchloride In ethanol for 18h; Reflux;	100%
With hydrogenchloride In ethanol; water at 90℃; for 24h;	45%

trimethylacetylacetonitrile (59997-51-2) + n-propylhydrazine oxalate (6340-91-6) → 3-tert-butyl-1-n-propyl-1H-pyrazol-5-amine (884340-11-8)

Conditions	Yield
With hydrogenchloride In ethanol for 12h; Reflux;	100%
Stage #1: trimethylacetylacetonitrile; n-propylhydrazine oxalate In ethanol at 85℃; Stage #2: With sodium hydroxide In dichloromethane; water	98%
In ethanol at 85℃; for 4h;	96%
In ethanol for 18h; Reflux; Inert atmosphere;

trimethylacetylacetonitrile (59997-51-2) + (R)-((tetrahydrofuran-2-yl)methyl)hydrazine dihydrochloride → (R)-3-tert-butyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine (1140917-39-0)

Conditions	Yield
Stage #1: trimethylacetylacetonitrile; (R)-((tetrahydrofuran-2-yl)methyl)hydrazine dihydrochloride In ethanol at 85℃; Stage #2: With sodium hydrogencarbonate In dichloromethane at 20℃;	100%

trimethylacetylacetonitrile (59997-51-2) + 3,3,3-trifluoropropyl-4-methylbenzene sulphonate (2342-67-8) → 3-tert-butyl-1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-amine (1217419-66-3)

Conditions	Yield
Stage #1: 3,3,3-trifluoropropyl-4-methylbenzene sulphonate With hydrazine hydrate In ethanol at 85℃; Stage #2: trimethylacetylacetonitrile In ethanol at 20 - 85℃; Reflux;	100%

2,4-difluorophenylhydrazine (40594-30-7) + trimethylacetylacetonitrile (59997-51-2) → 3-tert-butyl-1-(2,4-difluorophenyl)-1H-pyrazol-5-amine (778611-49-7)

Conditions	Yield
With hydrogenchloride In ethanol Reflux;	100%

trimethylacetylacetonitrile (59997-51-2) + benzylhydrazine dihydrochloride (20570-96-1) → 1-benzyl-3-tert-butyl-1H-pyrazol-5-amine (866255-96-1)

Conditions	Yield
With hydrogenchloride In ethanol Reflux;	100%

trimethylacetylacetonitrile (59997-51-2) + 3,4-dimethylphenylhydrazine hydrochloride (60481-51-8, 86746-50-1) → 5-tert-butyl-2-(3,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine (1025893-78-0)

Conditions	Yield
With hydrogenchloride In ethanol for 18h; Reflux;	100%
In methanol for 0.266667h; Reflux;	91.5%
In ethanol for 5h; Reflux;	90%

trimethylacetylacetonitrile (59997-51-2) + 4-hydrazinobenzoic acid hydrochloride (24589-77-3, 52455-33-1) → 4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoic acid (869663-56-9)

Conditions	Yield
With hydrogenchloride In ethanol for 18h; Reflux;	100%
Stage #1: trimethylacetylacetonitrile; 4-hydrazinobenzoic acid hydrochloride In ethanol for 69h; Reflux; Stage #2: With water; lithium hydroxide In tetrahydrofuran at 20℃; for 2h;

trimethylacetylacetonitrile (59997-51-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → (E/Z)-2-((dimethylamino)methylene)-4,4-dimethyl-3-oxopentanenitrile

Conditions	Yield
In toluene	100%

trimethylacetylacetonitrile (59997-51-2) + (3-chloro-4-fluorophenyl)hydrazine hydrochloride → 5-tert-butyl-2-(3-chloro-4-fluorophenyl)pyrazol-3-amine (1001522-07-1)

Conditions	Yield
With hydrogenchloride In ethanol for 18h; Reflux;	100%
In ethanol; water Reflux;

trimethylacetylacetonitrile (59997-51-2) + p-tolylhydrazine hydrochloride (637-60-5) → 3-tert-butyl-1-p-tolyl-1H-pyrazol-5-amine (285984-25-0)

Conditions	Yield
In methanol	99%
With hydrogenchloride In ethanol for 48h; Reflux;	86%
With hydrogenchloride In ethanol at 80℃; for 8h;	86.4%

trimethylacetylacetonitrile (59997-51-2) + 4-Hydrazinobenzoic acid (619-67-0) → 4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoic acid (869663-56-9)

Conditions	Yield
With acetic acid In tetrahydrofuran; ethanol for 16h; Heating / reflux;	99%
With acetic acid In tetrahydrofuran; ethanol for 16h; Heating / reflux;	99%
Stage #1: trimethylacetylacetonitrile; 4-Hydrazinobenzoic acid In methanol at 20℃; for 0.333333h; Stage #2: With hydrogenchloride at 94.85℃; for 0.666667h;	80%
In toluene at 20℃; for 12h; Heating / reflux;
In toluene at 20℃; for 12h; Heating / reflux;

trimethylacetylacetonitrile (59997-51-2) + 4-hydrazinobenzonitrile hydrochloride (2863-98-1) → 4-(5-amino-3-(tert-butyl)-1H-pyrazol-1-yl)benzonitrile (869663-55-8)

Conditions	Yield
With hydrogenchloride In ethanol for 18h; Reflux;	99%
In ethanol for 68h; Reflux;	95%
In ethanol at 20℃; for 92h; Reflux;	95%

trimethylacetylacetonitrile (59997-51-2) + benzaldehyde (100-52-7) → 4,4-dimethyl-3-oxo-2-[1-phenylmeth-(E)-ylidene]pentanenitrile (1189116-34-4)

Conditions	Yield
With L-proline In ethanol at 20℃; for 24h; Knoevenagel condensation;	99%
With dimethyl 3-methyl-9-oxo-7-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-2,4-di(pyridin-2-yl)-3,7-diazabicyclo-[3.3.1]nonane-1,5-dicarboxylate In water at 40℃; for 4h; Knoevenagel Condensation;	80%

trimethylacetylacetonitrile (59997-51-2) + (4-fluorobenzyl)hydrazine dihydrochloride → 3-tert-butyl-1-(4-fluorobenzyl)-1H-pyrazol-5-amine (1217414-99-7)

Conditions	Yield
Stage #1: trimethylacetylacetonitrile; (4-fluorobenzyl)hydrazine dihydrochloride In ethanol at 85℃; for 2h; Stage #2: With sodium hydrogencarbonate In ethanol; water; ethyl acetate	99%

trimethylacetylacetonitrile (59997-51-2) + benzaldehyde (100-52-7) + malononitrile (109-77-3) → 2-amino-6-(tert-butyl)-4-phenyl-4H-pyran-3,5-dicarbonitrile

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride In ethanol; water at 25℃; for 2h; Schlenk technique; Irradiation; Green chemistry;	98.6%
In ethanol; water at 20℃; Irradiation; Green chemistry;	88%

trimethylacetylacetonitrile (59997-51-2) + p-tolylhydrazine hydrochloride (637-60-5) → 3-amino-5-tert-butyl-2-(p-tolyl)-2H-pyrazole hydrochloride

Conditions	Yield
In methanol at 120℃; for 1h; microwave irradiation;	98%
In methanol Inert atmosphere; Reflux;	94%
In methanol for 16h; Reflux;	86%

trimethylacetylacetonitrile (59997-51-2) + 5-isothiocyanato-benzo[1,3]dioxole (113504-93-1) + methyl iodide (74-88-4) → 3-(benzo[1,3]dioxol-5ylamino)-2-(2,2-dimethylpropionyl)-3-methylsulfanyl-2-propenenitrile

Conditions	Yield
Stage #1: trimethylacetylacetonitrile; 5-isothiocyanato-benzo[1,3]dioxole With potassium carbonate In acetone at 20℃; for 72h; Stage #2: methyl iodide In acetone at 20℃; for 0.75h;	98%

trimethylacetylacetonitrile (59997-51-2) + 2C6H5O2(1-)*C16H22N2O2S4(2+) → C22H20N2O4S4 (1118625-18-5)

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 80℃; for 4h; Inert atmosphere;	98%

trimethylacetylacetonitrile (59997-51-2) + 2C6H5O2(1-)*C16H22N2O2S4(2+) → C22H20N2O4S4 (1118625-18-5)

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 80℃; for 4h; Inert atmosphere;	98%

trimethylacetylacetonitrile (59997-51-2) + (2-methoxyethyl)hydrazine oxalic acid → 5-tert-butyl-2-(2-methoxyethyl)-2H-pyrazol-3-ylamine

Conditions	Yield
In ethanol at 85℃; for 4.5h;	98%
In ethanol at 85℃; for 4.5h;	98%

trimethylacetylacetonitrile (59997-51-2) → 5-amino-3-tert-butylisoxazole (59669-59-9)

Conditions	Yield
With sodium hydroxide; hydroxyammonium sulfate at 100℃; for 2.5h;	97.6%
With hydroxylamine hydrochloride; sodium hydroxide In water at 100℃; for 2.5h;	97%
With hydroxylamine hydrochloride; sodium hydroxide In water at 60℃; for 3h;	88%

trimethylacetylacetonitrile (59997-51-2) → methyl 4,4-dimethyl-3-oxopentanimidate hydrochloride

Conditions	Yield
With hydrogenchloride In methanol; hexane; toluene	97.5%
	97.5%

trimethylacetylacetonitrile (59997-51-2) → 3-tert-butyl-1H-pyrazole-5-amine (82560-12-1)

Conditions	Yield
With hydrazine hydrate In methanol at 120℃; for 0.666667h; microwave irradiation;	97%
With hydrazine hydrate In ethanol at 110℃; for 7h; Inert atmosphere;	97%
With hydrazine hydrate In ethanol for 3h; Reflux;	89%

2-hydroxyethylhydrazine (109-84-2) + trimethylacetylacetonitrile (59997-51-2) → 2-(5-amino-3-(tert-butyl)-1H-pyrazol-1-yl)ethanol (908267-36-7)

Conditions	Yield
With hydrogenchloride In ethanol for 20h; Reflux;	97%
With hydrogenchloride In ethanol for 20h; Reflux;	97%
With hydrogenchloride In ethanol; water for 20h; Reflux;	97%

trimethylacetylacetonitrile (59997-51-2) + (R)-((tetrahydrofuran-2-yl)methyl)hydrazine dihydrochloride → (R)-3-tert-butyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine hydrochloride (1140917-98-1)

Conditions	Yield
In ethanol at 90℃; for 6h;	97%
In ethanol at 90℃; for 6h;	97%

trimethylacetylacetonitrile (59997-51-2) + (2-chloro-5-hydrazino-phenyl)-methanol → [5-(5-amino-3-tert-butyl-pyrazol-1-yl)-2-chloro-phenyl]-methanol hydrochloride

Conditions	Yield
With hydrogenchloride In ethanol for 3.5h; Reflux;	97%
With hydrogenchloride In ethanol for 3.5h; Reflux;	97%

trimethylacetylacetonitrile (59997-51-2) + 2-hydrazinoethanol → 2-(5-amino-3-(tert-butyl)-1H-pyrazol-1-yl)ethanol (908267-36-7)

Conditions	Yield
With hydrogenchloride In ethanol; water for 20h; Reflux;	97%

Upstream product

• 3282-30-2 pivaloyl chloride 
• 372-09-8 cyanoacetic acid 
• 13547-70-1 1-chloro-3,3-dimethyl-butan-2-one 
• 151-50-8 potassium cyanide 
• 75-05-8 acetonitrile 
• 773837-37-9 sodium cyanide 
• 5469-26-1 1-Bromopinacolon 
• 598-98-1 Methyl pivalate 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 3938-95-2 2,2-dimethyl-propanoic acid ethyl ester 
• 1132-15-6 3,5-di(tert-butyl )isoxazole 
• 143-33-9 sodium cyanide 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 

Downstream Products

• 219866-68-9 4,4-Dimethyl-3-oxo-2,2-difluoropentane nitrile 
• 890130-35-5 3-tert-butyl-1-[4-(propan-2-yl)phenyl]-1H-pyrazol-5-amine 
• 476637-05-5 2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl-amine 
• 251658-55-6 3-(tert-butyl)-1-(4-nitrophenyl)-1H-pyrazol-5-amine 
• 337533-96-7 5-tert-butyl-2-o-tolyl-2H-pyrazol-3-yl-amine 
• 778611-16-8 3-(tert-butyl)-1-(4-fluorophenyl)-1H-pyrazol-5-amine 
• 55809-36-4 3-amino-5-tert-butylisoxazole 
• 92745-97-6 3-tert-butyl-2H-isoxazol-5-one 
• 917950-33-5 5-amino-3-tert-butyl-1-phenyl-1H-pyrazole hydrochloride 
• 1159001-71-4 4,4-dimethyl-3-(p-tolylamino)pent-2-enenitrile 
• 725685-92-7 3-(5-amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid ethyl ester 
• 898537-77-4 3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-amine 
• 945994-85-4 5-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)-2-chlorophenol 

Relevant articles and documents

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Microwave synthesis of 1-aryl-1H-pyrazole-5-amines

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