60081-20-1Relevant articles and documents
Δ9-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled Δ9-tetrahydrocannabinol
Qi, Longwu,Yamamoto, Noboru,Meijler, Michael M.,Altobell III, Laurence J.,Koob, George F.,Wirsching, Peter,Janda, Kim D.
, p. 7389 - 7399 (2007/10/03)
Immunopharmacotherapy as an approach to combat drugs of abuse has become an active area of investigation. Marijuana is the most commonly used illicit drug in the U.S. The main active chemical in marijuana is Δ9- tetrahydrocannabinol (Δ9-THC); hence, monoclonal antibodies with high affinity and specificity for Δ9-tetrahydrocannabinol could be valuable immunopharmacotherapeutic intervention and diagnostic tools. We have synthesized immunoconjugates that induce an effective immune response to Δ9-THC and describe a convenient synthesis of radiolabeled Δ9-THC. We demonstrate the value and use of this probe to select anti-Δ9-THC antibodies that bind Δ9-THC with good affinity. The synthetic route to radiolabeled Δ9-THC has enabled the correct assessment of the affinity of these antibodies to their ligand and may facilitate future binding studies between Δ9- THC and its analogues and the cannabinoid receptors.
Benzopyrans having an unsaturated side chain
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, (2008/06/13)
3-Formyl-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol, ethers and esters thereof having the formula STR1 wherein R is hydrogen, lower alkyl or lower alkanoyl and R6 is formyl or 1,3-dithiolan-2-yl but is 1,3-dithiolan-2-yl only when R is hydrogen, and derivatives thereof of the formula STR2 wherein R1 is hydrogen or lower alkanoyl, R2 is alkyl, aryl-lower alkyl or cycloalkyl-lower alkyl, A represents STR3 when R1 is hydrogen and R3 is lower alkyl, and A is STR4 when R1 is lower alkanoyl and R4 is the same lower alkanoyl represented by R1, processes of making such compounds and intermediates useful in such processes, pharmaceutical compositions containing the compounds and the use of the compounds as tranquilizing and antidepressant agents.