60103-17-5

Basic information

• Product Name: 11-alpha,17-alpha,21-trihydroxypregn-4-ene-3,20-dione
• Synonyms: 11-alpha,17-alpha,21-trihydroxypregn-4-ene-3,20-dione;11,17α,21-Trihydroxypregna-4-ene-3,20-dione;Einecs 262-053-8
• CAS NO: 60103-17-5
• Molecular Formula: C21H30O5
• Molecular Weight: 362.4599
• EINECS: 262-053-8
• Mol File: 60103-17-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 566.4 °C at 760 mmHg
• Flash Point: 310.4 °C
• Appearance: /
• Density: 1.28 g/cm³
• CAS DataBase Reference: 11-alpha,17-alpha,21-trihydroxypregn-4-ene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 11-alpha,17-alpha,21-trihydroxypregn-4-ene-3,20-dione(60103-17-5)
• EPA Substance Registry System: 11-alpha,17-alpha,21-trihydroxypregn-4-ene-3,20-dione(60103-17-5)

Safety Data

• Hazardous Substances Data: 60103-17-5(Hazardous Substances Data)

Usage

Chemical classification

Steroid hormone

Type

Progesterone derivative

Function

Crucial hormone in female reproductive system

Properties

Potent anti-inflammatory and immunosuppressive effects

Medical uses

Treatment of menstrual disorders, endometriosis, and certain types of cancer

Application

Component of hormonal contraceptives

Mechanism of action

Binds to progesterone receptors in the body, affecting reproductive health and inflammation-related physiological processes

Chemical structure

11-alpha,17-alpha,21-trihydroxypregn-4-ene-3,20-dione

Synthetic origin

Synthetic derivative of progesterone

Target receptors

Progesterone receptors

Impact on body

Affects various physiological processes related to reproductive health and inflammation

Upstream product

• 152-58-9 C₂₁H₃₀O₄ 

Downstream Products

• 50-03-3 11β,17α,21-trihydroxypregn-4-ene-3,20-dione-21-acetate 
• 6818-44-6 4-((3R,5S,7R,10S,12S,13R)-3,7,12-Triacetoxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester 
• 807-05-6 17α.20;20.21-Bis-methylendioxy-pregnen-(4)-ol-(11β)-on-(3); 'Bismethylendioxy-hydrocortison' 

Relevant articles and documents

Dehalogenation methodof 9-halogenated steroid compound and application

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.

Transformation of progesterone by Aspergillus niger 100 and Rhizopus nigricans REF, 129.

-