6011-14-9 Usage
Chemical Properties
White to light brown solid
Uses
Used as pharmaceutical intermediates, organic synthetic raw material transportation.
Application
Aminoacetonitrile is a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors.
Preparation
Synthesis of Aminoacetonitrile Hydrochloride by Reaction of Aminoacetonitrile with Hydrogen Chloride in Methanol: mixing the aminoacetonitrile with hydrogen chloride methanol solution, reacting at 45-50°C for 1-2 hours, cooling to below 5°C, filtering, and centrifugalizing to obtain the aminoacetonitrile hydrochloride, wherein in the hydrogen chloride methanol solution, the content of hydrogen chloride is 30-50 wt%, and the water content is less than or equal to 1%.Preparation method of aminoacetonitrile hydrochloride
Safety Profile
An experimental
teratogen. Experimental reproductive
effects. When heated to decomposition it
emits toxic fumes of NOx and HCl.
Purification Methods
The salt recrystallises from dilute EtOH as hygroscopic leaflets. It is best to crystallise it from absolute EtOH/Et2O (1:1) and then recrystallise it from absolute EtOH. The melting point recorded ranges from 144o to 174o. The free base has b 58o/15mm with partial decomposition. [Klages J Prakt Chem [2] 65 189 1902, Mange J Am Chem Soc 56 2197 1934, Goldberg & Kelly J Chem Soc 1371 1947, Beilstein 4 H 344, 4 I 468, 4 II 783, 4 III 1120, 4 IV 2363.]
Check Digit Verification of cas no
The CAS Registry Mumber 6011-14-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,1 and 1 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6011-14:
(6*6)+(5*0)+(4*1)+(3*1)+(2*1)+(1*4)=49
49 % 10 = 9
So 6011-14-9 is a valid CAS Registry Number.
InChI:InChI=1/C2H4N2.ClH/c3-1-2-4;/h1,3H2;1H
6011-14-9Relevant articles and documents
Enabling iron catalyzed Doyle-Kirmse rearrangement reactions with: In situ generated diazo compounds
Hock, Katharina J.,Mertens, Lucas,Hommelsheim, Renè,Spitzner, Robin,Koenigs, Rene M.
, p. 6577 - 6580 (2017)
Slow addition of sodium nitrite allows the in situ preparation of highly explosive diazo compounds and enables their safe and scalable application in iron catalyzed rearrangement reactions of allylic and propargylic sulfides. With catalyst loadings as low as 0.1 mol% an effective entry into α-mercapto-nitriles, α-mercapto-esters and α-trifluoromethyl-sulfides on a gram-scale is achieved.
Fluorobenzamides and uses thereof
-
, (2008/06/13)
The invention relates to fluorobenzamide derivatives of the formula wherein R1, R2, R3 R4, R5, R6 and R7 are as defined herein. =, The compounds of the invention are selective monoamine oxidase B inhibitors and therefore they are suitable for the treatment of diseases mediated by monoamine oxidase B, such as Alzheimer's disease or senile dementia.
