6024-83-5

Basic information

• Product Name: d-tetrahydropalmatine
• Synonyms: D-TETRAHYDROPALMATINE HYDROCHLORIDE;D-TETRAHYDROPALMATINE HYDROCHLORI;(13aR)-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine hydrochloride (1:1);(R)-Tetrahydropalmatine hydrochloride;NSC 132058;13abeta-Berbine, 2,3,9,10-tetramethoxy-, hydrochloride (8CI)
• CAS NO: 6024-83-5
• Molecular Formula: C21H26ClNO4
• Molecular Weight: 391.88844
• Product Categories: Miscellaneous Natural Products
• Mol File: 6024-83-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 482.9°Cat760mmHg
• Flash Point: 138.7°C
• Appearance: /
• Density: 1.23g/cm³
• CAS DataBase Reference: d-tetrahydropalmatine(CAS DataBase Reference)
• NIST Chemistry Reference: d-tetrahydropalmatine(6024-83-5)
• EPA Substance Registry System: d-tetrahydropalmatine(6024-83-5)

Safety Data

• Hazardous Substances Data: 6024-83-5(Hazardous Substances Data)

Usage

General Description

D-tetrahydropalmatine, also known as THP, is a chemical compound found in various plant species such as Corydalis and Stephania. It has been used in traditional Chinese medicine for its potential medicinal properties, including its ability to act as a mild sedative, anxiolytic, and analgesic. Studies have shown that d-tetrahydropalmatine may have potential therapeutic effects in the treatment of substance abuse, depression, and anxiety disorders. Additionally, it has been investigated for its potential role in modulating dopamine and serotonin levels in the brain, which could contribute to its neuroprotective and antidepressant effects. While further research is needed to fully understand its mechanisms and potential therapeutic applications, d-tetrahydropalmatine shows promise as a natural compound with medicinal properties.

Upstream product

• 3520-14-7 (R)-(+)-tetrahydropalmatine 
• 483-14-7 tetrahydropalmatine 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING NASH, NAFLD, AND OBESITY

The present technology relates to methods of treating NASH, NAFLD and/or obesity using compounds of Formulas I, II, III, IV, V, and/or VI. The methods include administering to a subject suffering from one or more of non-alcoholic steatohepatitis (NASH), non- alcoholic fatty liver disease (NAFLD) and/or obesity a therapeutically effective amount of such a compound

Compounds and Compositions for Modulating Lipid Levels and Methods of Preparing Same

The present technology relates to compounds of Formulas I-VI and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also increase HDL-C, lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated protein kinase.

COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING LIPID LEVELS

Compositions comprising extracts or isolated or purified compounds from plants of the genus Corydalis provide prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Corydalis compounds and their derivatives of natural and synthetic origins lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression and activate AMP-activated protein kinase. Specific stereoisomers of Corydalis compounds with lipid lowering activity include 14R-(+)-corypalmine, 14R,13S-(+)-corydaline, 14R-(+)-tetrahydropalmatin, (+)-corlumidin, d-(+)-bicuculline, and (+)-egenine.