60260-49-3

Basic information

• Product Name: Sulfamoyl chloride, phenyl-
• Synonyms: phenylsulfamoylchloride;benzenesulfamyl chloride;N-phenylsulfamoyl chloride;Phenylsulfamoyl chloride;phenyl sulfamoyl chloride
• CAS NO: 60260-49-3
• Molecular Formula: C6H6ClNO2S
• Molecular Weight: 191.638
• Mol File: 60260-49-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 130 °C (2.5 mmHg)
• CAS DataBase Reference: Sulfamoyl chloride, phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfamoyl chloride, phenyl-(60260-49-3)
• EPA Substance Registry System: Sulfamoyl chloride, phenyl-(60260-49-3)

Safety Data

• Hazardous Substances Data: 60260-49-3(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 3345-86-6 N-phenylsulfamic acid 
• 15790-84-8 sodium phenylsulfamate 

Downstream Products

• 1316251-34-9 C₁₆H₂₅N₃O₄S 
• 1320252-43-4 C₂₂H₂₄N₄O₈S 
• 104254-89-9 Benzyl-phenyl-sulfamic acid cyclohexyl ester 
• 104254-88-8 Pentyl-phenyl-sulfamic acid cyclohexyl ester 
• 104254-90-2 Allyl-phenyl-sulfamic acid cyclohexyl ester 
• 104239-25-0 Phenyl-propyl-sulfamic acid cyclohexyl ester 
• 104239-24-9 Ethyl-phenyl-sulfamic acid cyclohexyl ester 

Relevant articles and documents

Regioselective Radical Arene Amination for the Concise Synthesis ofortho-Phenylenediamines

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactiveN-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the areneorthoposition. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly toortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsymmetrical, selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuableortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

3-DIARYLMETHYLENES AND USES THEREOF

3-Diarylmethylenes are disclosed. The compounds activate PP2A, suppress oncogenic kinase signaling, and negatively regulate MYC and MYCN in cancer. The compounds also induce FOXO transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.

PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.