60290-21-3

Basic information

• Product Name: 4-CHLORO-5-AZAINDOLE
• Synonyms: 4-CHLORO-5-AZAINDOLE;4-CHORO-5-AZAINDOLE;1H-Pyrrolo[3,2-c]pyridine, 4-chloro-;4-Chloro-1H-pyrrolo[3,2-c]pyridine 95%
• CAS NO: 60290-21-3
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.581
• Product Categories: Heterocycle-Pyridine series
• Mol File: 60290-21-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 189-192 °C(Solv: acetonitrile (75-05-8))
• Boiling Point: 335.794 °C at 760 mmHg
• Flash Point: 187.228 °C
• Appearance: /
• Density: 1.425 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.703
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 14.30±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-5-AZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-AZAINDOLE(60290-21-3)
• EPA Substance Registry System: 4-CHLORO-5-AZAINDOLE(60290-21-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-41
• Safety Statements: 26-45
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 60290-21-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 60290-21-3 differently. You can refer to the following data:
1. 4-CHLORO-5-AZAINDOLE is an intermediate used in the synthetic preparation of potent gp120-CD4 inhibitors.
2. 4-Chloro-1H-pyrrolo[3,2-c]pyridine is an intermediate used in the synthetic preparation of potent gp120-CD4 inhibitors.

InChI:InChI=1/C7H5ClN2/c8-7-5-1-3-9-6(5)2-4-10-7/h1-4,9H

Upstream product

• 109113-39-5 1-Benzenesulfonyl-1H-pyrrolo<3,2-c>pyridine 
• 271-34-1 5-azaindole 
• 209286-78-2 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[3,2-c]pyridine 
• 494767-29-2 C₇H₇ClN₂ 
• 26956-47-8 1-benzyl-4,5-dihydro-4-oxopyrrolo<3,2-c>pyridine 
• 54415-77-9 4,5-dihydro-4-oxo-1H-pyrrolo<3,2-c>pyridine 

Downstream Products

• 209286-78-2 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[3,2-c]pyridine 
• 947238-42-8 3-bromo-4-chloro-5-azaindole 
• 27382-01-0 1-methyl-4-chloro-1H-pyrrolo<3,2-c>pyridine 
• 271-34-1 5-azaindole 
• 944900-76-9 4-methoxy-1H-pyrrolo[3,2-c]pyridine 
• 35636-10-3 benzyl-1 chloro-4 pyrrolo<3,2-c>pyridine 

Relevant articles and documents

3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF

7-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 7-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists

A series of TRPA1 antagonists is described having a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine or a 1-aryloxyisoquinoline scaffold. These compounds have high ligand efficiency and favorable physical properties and may thus serve as scaffolds for further optimization.